CAJ | 학술논문

目的：评价艾司西酞普兰与帕罗西汀治疗单项抑郁症的临床疗效及安全性。方法将71例单项抑郁症患者随机分为艾司西酞普兰组37例和帕罗西汀组34例。艾司西酞普兰组口服10 mg? d-1艾司西酞普兰，最大剂量20 mg? d-1，疗程为12周；帕罗西汀组口服20 mg? d-1帕罗西汀，最大剂量50 mg? d-1，疗程为12周。2组分别于治疗前、治疗2，4，8和12周用汉密尔顿抑郁量表（HAMD）、抑郁自评量表（SDS）及不良反应症状量表（TESS）评价2组的临床疗效及安全性。结果服药4周后，艾司西酞普兰组HAMD及SDS评分较治疗前显著降低（ P＜0.05）。服药2周后，帕罗西汀组HAMD及SDS较治疗前显著降低（ P ＜0.05）。治疗后，艾司西酞普兰组 HAMD 评分总有效率为72.97％，SDS评分总有效率为70.27％；帕罗西汀组 HAMD 评分总有效率为70.59％，SDS 评分总有效率为67.65％，2组患者比较差异无统计学意义（ P＞0.05）。2组患者不良反应发生率差异无统计学意义（ P＞0.05）。结论艾司西酞普兰和帕罗西汀治疗单项抑郁症的总体疗效和不良反应无明显差异，但帕罗西汀起效较艾司西酞普兰快。
목적：평개애사서태보란여파라서정치료단항억욱증적림상료효급안전성。방법장71례단항억욱증환자수궤분위애사서태보란조37례화파라서정조34례。애사서태보란조구복10 mg? d-1애사서태보란，최대제량20 mg? d-1，료정위12주；파라서정조구복20 mg? d-1파라서정，최대제량50 mg? d-1，료정위12주。2조분별우치료전、치료2，4，8화12주용한밀이돈억욱량표（HAMD）、억욱자평량표（SDS）급불량반응증상량표（TESS）평개2조적림상료효급안전성。결과복약4주후，애사서태보란조HAMD급SDS평분교치료전현저강저（ P＜0.05）。복약2주후，파라서정조HAMD급SDS교치료전현저강저（ P ＜0.05）。치료후，애사서태보란조 HAMD 평분총유효솔위72.97％，SDS평분총유효솔위70.27％；파라서정조 HAMD 평분총유효솔위70.59％，SDS 평분총유효솔위67.65％，2조환자비교차이무통계학의의（ P＞0.05）。2조환자불량반응발생솔차이무통계학의의（ P＞0.05）。결론애사서태보란화파라서정치료단항억욱증적총체료효화불량반응무명현차이，단파라서정기효교애사서태보란쾌。
Objective To evaluate the clinical effects and toxicity of escitalopram oxalate versus paroxetine in the treatment of unipolar depre-ssion.Methods 71patientswithconfirmeddiagnosisofunipolardepre-ssion ( UD ) were recruited and randomized divided in to escitalopram oxalate ( EO ) group with escitalopram oxalate 10 mg? d-1 ( max 20 mg? d-1 ) orally, and paroxetine ( PA ) group with paroxetine 20 mg? d-1 ( max 50 mg? d -1 ) orally, with 12 weeks treatment.At the time point of 2 , 4 , 8 and 12 -week the hamilton depression scale (HAMD), self-rating depression scale (SDS) and treatment emergent symptom scale ( TESS ) score were recorded and compared between the two groups. Results The HAMD and SDS score were significant decreased ( P<0.05 ) after 4 weeks treatment in the EO group , and sig-nificant decreased ( P<0.05 ) after 2 week in the PA group.The clinical efficacy was 72.97%and 70.27% according to HAMD and SDS in the EO group.The clinical efficacy was 70.59% and 67.65% according to HAMD and SDS in the PA group .No statistical difference was found between the two groups for the clinical efficacy (P>0.05).There was no significant difference between two group on incidence of adverse drug reaction ( P>0.05 ).Conclusion There was no significant difference for escitalopram oxalate and paroxetine in the treatment of unipolar depression , but paroxetine work quickly than escitalopram oxalate .