CAJ | 학술논문

目的：评价氟比洛芬酯与地佐辛预防骨科手术后躁动的疗效及安全性。方法90例美国麻醉医师协会分级标准（ASA）Ⅰ～Ⅱ级择期进行骨科全麻手术患者随机分为氟比洛芬酯（A组），地佐辛组（B组），对照组（C组），每组各30例，术中给予相同的麻醉诱导和维持方案，手术结束前15 min，A组静脉注射比洛芬酯予1 mg? kg-1，B组静脉注射地佐辛10 mg，C组给予0.9％ NaCl溶液2 mL。记录每组患者的拔管时间，躁动评分及躁动发生事件，拔管后5 min疼痛评分，拔管前后的平均动脉压、心率及术后不良反应发生率。结果 A，B组的躁动发生率、拔管后5 min疼痛评分均显著低于C组（ P＜0.05），但B组的恶心、呕吐等不良反应发生率显著高于A，C组（ P＜0.05）。结论手术结束前15 min，骨科全麻手术患者静脉滴注氟比洛芬酯1 mg? kg-1可有效减少术后躁动的发生率，且术后不良反应发生率低。
목적：평개불비락분지여지좌신예방골과수술후조동적료효급안전성。방법90례미국마취의사협회분급표준（ASA）Ⅰ～Ⅱ급택기진행골과전마수술환자수궤분위불비락분지（A조），지좌신조（B조），대조조（C조），매조각30례，술중급여상동적마취유도화유지방안，수술결속전15 min，A조정맥주사비락분지여1 mg? kg-1，B조정맥주사지좌신10 mg，C조급여0.9％ NaCl용액2 mL。기록매조환자적발관시간，조동평분급조동발생사건，발관후5 min동통평분，발관전후적평균동맥압、심솔급술후불량반응발생솔。결과 A，B조적조동발생솔、발관후5 min동통평분균현저저우C조（ P＜0.05），단B조적악심、구토등불량반응발생솔현저고우A，C조（ P＜0.05）。결론수술결속전15 min，골과전마수술환자정맥적주불비락분지1 mg? kg-1가유효감소술후조동적발생솔，차술후불량반응발생솔저。
Objective To observe the effect and safety of flurbiprofen axetil and dezocine for the prevention against postoperative agitation on patients undergoing orthopedic surgery .Methods Ninety patients with gradeⅠ-Ⅱaccording to the classification of American society of anes-thesiologists ( ASA ) undergoing orthopedic surgery in general anesthesia were randomly assigned to the flurbiprofen axetil group ( group A) , dezo-cine group ( group B ) and control group ( group C ) .Patients in each group were respectively injected with flurbiprofen axetil 1 mg? kg -1 , dezocine 10 mg, and 0.9% NaCl 2 mL intravenously 15 minutes before the end of surgery.The data of time of endotracheal intubation removal, scale of postoperative agitation and the incidence of postoperative agita-tion, verbal rating scale (VRS) for pain 5 minutes after endotracheal in-tubation removal, mean arterial pressure (MAP) and heart rate (HR), postoperative adverse drug reactions were observed and recorded before the end of endotracheal intubation removal .Results The postoperative agitation and VRS in group A and B were significantly lower than those in group C (P<0.05), and adverse drug reactions such as nausea and vomiting in group B were significantly higher than those in group A and C ( P <0.05 ) .Conclusion Intravenous injection of flurbiprofen axetil 1 mg? kg -1 15 minutes before the end of the surgery would effectively reduce postoperative agitation in patients undergoing orthopedic surgery under general anesthesia , and adverse drug reactions would not be increased .