CAJ | 학술논문

目的：评价氯诺昔康与曲马多对肝癌术后自控镇痛的临床疗效和安全性。方法将54例全麻下肝癌手术患者随机分为试验组28例和对照组26例。试验组予以氯诺昔康96 mg+0.9％氯化钠至150 mL，自控镇痛泵入；对照组予以曲马多96 mg+0.9％氯化钠至150 mL，自控镇痛泵入。于术后4，12，24，48 h，用视觉模拟评分法和舒适度评分法对患者进行镇痛及舒适度评价；同时记录2组患者术后48h内不良反应发生率。结果2组患者术后各时点镇痛及舒适度评分比较，差异无统计学意义（ P＞0.05）。试验组不良反应发生率为14.3％，对照组不良反应发生率为19.2％（ P＞0.05）。结论氯诺昔康与曲马多均可用于肝癌术后自控镇痛，其临床疗效及不良反应无显著差异。
목적：평개록낙석강여곡마다대간암술후자공진통적림상료효화안전성。방법장54례전마하간암수술환자수궤분위시험조28례화대조조26례。시험조여이록낙석강96 mg+0.9％록화납지150 mL，자공진통빙입；대조조여이곡마다96 mg+0.9％록화납지150 mL，자공진통빙입。우술후4，12，24，48 h，용시각모의평분법화서괄도평분법대환자진행진통급서괄도평개；동시기록2조환자술후48h내불량반응발생솔。결과2조환자술후각시점진통급서괄도평분비교，차이무통계학의의（ P＞0.05）。시험조불량반응발생솔위14.3％，대조조불량반응발생솔위19.2％（ P＞0.05）。결론록낙석강여곡마다균가용우간암술후자공진통，기림상료효급불량반응무현저차이。
Objective To evaluate the analgesia effect of lornoxicam versus tramadol patient controlled analgesia in hepatocellular carcinoma patients treated with surgery .Methods A total of 54 hepatocellular car-cinoma patients who were scheduled for operation were included , 28 pa-tients received lornoxicam patients controlled analgesia with lornoxicam 96 mg+0.9% NaCl up to 150 mL.And 26 patients received tramadol patients controlled analgesia with tramadol 96 mg+0.9%NaCl up to 150 mL.The visual analogue scale ( VAS ) and bruggrmann comfort scale (BCS) were recorded in the time point of 4,12,24 and 48 h.The adverse event such as nausea , vomiting and dizziness were compared between the two groups.Results The VAS and BCS had no statistical difference between the two group in each of the time points ( P>0.05 ) . The adverse event incidence were 14.3% and 19.2% in the lornoxicam and tramadol group respectively with no statistical difference ( P>0.05 ) . Conclusion Both lornoxicam versus tramadol were effective in patient con-trolled analgesia for hepatocellular carcinoma patients treated with surgery .