中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2015年
10期
796-798
,共3页
曾雪云%徐天生%徐建光%兰永平
曾雪雲%徐天生%徐建光%蘭永平
증설운%서천생%서건광%란영평
纤维结肠镜%无痛%右美托咪定%丙泊酚%安全性
纖維結腸鏡%無痛%右美託咪定%丙泊酚%安全性
섬유결장경%무통%우미탁미정%병박분%안전성
coloscopy%analgesic%dexmedetomidine%propofol%safety
目的：评价右美托咪定复合丙泊酚用于无痛纤维结肠镜检查术的临床疗效及安全性。方法将48例拟进行纤维结肠镜检查的患者随机分为试验组22例和对照组26例。对照组静脉注射丙泊酚2.5 mg? kg-1，术中根据患者麻醉情况追加0.5～1.0 mg? kg-1。试验组首先缓慢静脉推注（10 min ）右美托咪定1μg? kg-1，然后静脉注射丙泊酚2 mg? kg -1。2组患者麻醉后置入纤维结肠镜，并寻腔进镜对患者肠腔内壁进行检查。检查过程中分析比较2组患者的镇痛效果、起效时间、苏醒时间、离院时间及麻醉过程中的不良反应发生率有无差别。结果试验组镇痛效果明显优于对照组（ P＜0.05）。试验组起效时间、苏醒时间及离院时间均明显短于对照组，丙泊酚用量小于对照组（均P＜0.05）。试验组头晕及躁动发生率显著低于对照组（均P＜0.05），而恶心呕吐、舌后坠及呼吸抑制发生率比较差异均无统计学意义（ P＞0.05）。结论右美托咪定复合丙泊酚用于无痛纤维结肠镜检查镇痛效果好，不良反应发生率低。
目的：評價右美託咪定複閤丙泊酚用于無痛纖維結腸鏡檢查術的臨床療效及安全性。方法將48例擬進行纖維結腸鏡檢查的患者隨機分為試驗組22例和對照組26例。對照組靜脈註射丙泊酚2.5 mg? kg-1，術中根據患者痳醉情況追加0.5～1.0 mg? kg-1。試驗組首先緩慢靜脈推註（10 min ）右美託咪定1μg? kg-1，然後靜脈註射丙泊酚2 mg? kg -1。2組患者痳醉後置入纖維結腸鏡，併尋腔進鏡對患者腸腔內壁進行檢查。檢查過程中分析比較2組患者的鎮痛效果、起效時間、囌醒時間、離院時間及痳醉過程中的不良反應髮生率有無差彆。結果試驗組鎮痛效果明顯優于對照組（ P＜0.05）。試驗組起效時間、囌醒時間及離院時間均明顯短于對照組，丙泊酚用量小于對照組（均P＜0.05）。試驗組頭暈及躁動髮生率顯著低于對照組（均P＜0.05），而噁心嘔吐、舌後墜及呼吸抑製髮生率比較差異均無統計學意義（ P＞0.05）。結論右美託咪定複閤丙泊酚用于無痛纖維結腸鏡檢查鎮痛效果好，不良反應髮生率低。
목적：평개우미탁미정복합병박분용우무통섬유결장경검사술적림상료효급안전성。방법장48례의진행섬유결장경검사적환자수궤분위시험조22례화대조조26례。대조조정맥주사병박분2.5 mg? kg-1，술중근거환자마취정황추가0.5～1.0 mg? kg-1。시험조수선완만정맥추주（10 min ）우미탁미정1μg? kg-1，연후정맥주사병박분2 mg? kg -1。2조환자마취후치입섬유결장경，병심강진경대환자장강내벽진행검사。검사과정중분석비교2조환자적진통효과、기효시간、소성시간、리원시간급마취과정중적불량반응발생솔유무차별。결과시험조진통효과명현우우대조조（ P＜0.05）。시험조기효시간、소성시간급리원시간균명현단우대조조，병박분용량소우대조조（균P＜0.05）。시험조두훈급조동발생솔현저저우대조조（균P＜0.05），이악심구토、설후추급호흡억제발생솔비교차이균무통계학의의（ P＞0.05）。결론우미탁미정복합병박분용우무통섬유결장경검사진통효과호，불량반응발생솔저。
Objective To explicate the effects and safety of propofol com-bined with dexmedetomidine on analgesic coloscopy .Methods A total of 48 patients planed for analgesic coloscopy were randomly divided into control group ( n=26 ) and experiment group ( n=22 ) .Patients in the control group received propofol 2.5 mg? kg-1 with plus of 0.5 -1.0 mg? kg-1 intraoperatively and patients in the experiment group received dexmedetomidine 1μg? kg-1 firstly followed by propofol 2.5 mg? kg-1 . The procedure of fiber colonoscopy was done after anesthesia , the inner lumen was examined by the colonoscopy . In the procedure of examination , the analgesia effect time , wake up time , leave hospital time and incidence of odverse event between the two groups were compared . Results The analgesia effects was superior in the experiment compared with control group ( P <0.05 ) .The time of effectiveness recovery and leave hospital was significant shorter in experiment group compared with control group ( P <0.05 ) .The amount of propofol used in experiment group was smaller than control ( P <0.05 ) .The incidence of dizziness and restlessness was smaller in experiment group compared with control group ( P <0.05 ) . Conclusion Dexmedetomidine combined with propofol was efficacy and safe on analgesic coloscopy patients .
