中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2015年
10期
780-782
,共3页
复发性阿弗他溃疡%片仔癀%临床疗效%安全性%复发风险
複髮性阿弗他潰瘍%片仔癀%臨床療效%安全性%複髮風險
복발성아불타궤양%편자황%림상료효%안전성%복발풍험
recurrent aphthous ulcer%panzaihuang%efficacy%safety%recurrence risk
目的：评价片仔癀外涂联合口服治疗复发性阿弗他溃疡的临床疗效及安全性。方法66例复发性阿弗他溃疡患者随机分为试验组31例和对照组35例，对照组溃疡部位外涂锡类散，每天3次；口服牛黄解毒片，每次3片，每天3次，直至溃疡愈合。试验组取片仔癀1g制成粉末并涂在溃疡表面，每天3次，口服片仔癀，每次0.5 g，q6 h，同时服用牛黄解毒片，每天3次，每次3片，直至溃疡愈合。观察2组患者的溃疡愈合时间，临床疗效及愈合后1月内复发情况。结果试验组总有效率为100％，显著高于对照组的80.0％（ P＜0.05）。试验组口腔溃疡平均愈合时间为（3.0±0.8） d，对照组愈合时间为（4.8±1.2） d，试验组愈合时间显著低于对照组（ P＜0.05）。2组患者随访1月，试验组复发8例，对照组复发19例，试验组复发风险显著低于对照组（ P＜0.05）。2组患者用药期间均未发现明显的不良反应。结论片仔癀外涂联合口服治疗复发性阿弗他溃疡可加速溃疡愈合，减少复发风险，且不增加不良反应的发生率。
目的：評價片仔癀外塗聯閤口服治療複髮性阿弗他潰瘍的臨床療效及安全性。方法66例複髮性阿弗他潰瘍患者隨機分為試驗組31例和對照組35例，對照組潰瘍部位外塗錫類散，每天3次；口服牛黃解毒片，每次3片，每天3次，直至潰瘍愈閤。試驗組取片仔癀1g製成粉末併塗在潰瘍錶麵，每天3次，口服片仔癀，每次0.5 g，q6 h，同時服用牛黃解毒片，每天3次，每次3片，直至潰瘍愈閤。觀察2組患者的潰瘍愈閤時間，臨床療效及愈閤後1月內複髮情況。結果試驗組總有效率為100％，顯著高于對照組的80.0％（ P＜0.05）。試驗組口腔潰瘍平均愈閤時間為（3.0±0.8） d，對照組愈閤時間為（4.8±1.2） d，試驗組愈閤時間顯著低于對照組（ P＜0.05）。2組患者隨訪1月，試驗組複髮8例，對照組複髮19例，試驗組複髮風險顯著低于對照組（ P＜0.05）。2組患者用藥期間均未髮現明顯的不良反應。結論片仔癀外塗聯閤口服治療複髮性阿弗他潰瘍可加速潰瘍愈閤，減少複髮風險，且不增加不良反應的髮生率。
목적：평개편자황외도연합구복치료복발성아불타궤양적림상료효급안전성。방법66례복발성아불타궤양환자수궤분위시험조31례화대조조35례，대조조궤양부위외도석류산，매천3차；구복우황해독편，매차3편，매천3차，직지궤양유합。시험조취편자황1g제성분말병도재궤양표면，매천3차，구복편자황，매차0.5 g，q6 h，동시복용우황해독편，매천3차，매차3편，직지궤양유합。관찰2조환자적궤양유합시간，림상료효급유합후1월내복발정황。결과시험조총유효솔위100％，현저고우대조조적80.0％（ P＜0.05）。시험조구강궤양평균유합시간위（3.0±0.8） d，대조조유합시간위（4.8±1.2） d，시험조유합시간현저저우대조조（ P＜0.05）。2조환자수방1월，시험조복발8례，대조조복발19례，시험조복발풍험현저저우대조조（ P＜0.05）。2조환자용약기간균미발현명현적불량반응。결론편자황외도연합구복치료복발성아불타궤양가가속궤양유합，감소복발풍험，차불증가불량반응적발생솔。
Objective To evaluate the clinical efficacy and safety of Pianzaihuang in the treatment of recurrent aphthous ulcer .Methods A total of 66 cases with recurrent aphthous ulcer were randomly divided into treatment group ( n=31 ) and control group ( n=35 ) .Patients in control group were administered with the Xilei San , tid, and Niuhuang Jiedu Pian, tid, until the ulcer coalesced.Those in treatment group were treated with Pianzaihuang 1 g for external use and 0.5 g by oral adminis-tration, q6 h, plus Niuhuang Jiedu Pian , tid, until the ulcer coalesced. The data of healing time of ulcer , clinical efficacy and risk of recurrence were compared between the two groups .Results The total effective rate in experiment group was 100%, significantly higher than that in the control group ( 80.0%, P<0.05 ) .The mean ulcer healing time was ( 3.0 ±0.8 ) d and ( 4.8 ±1.2 ) d in two groups , which showed treatment group was significantly shorter ( P <0.05 ) .In one -month follow-up, there were 8 cases and 1 case reoccurred in treatment and control group , and the recurrence risk in the treatment group was signifi-cantly lower than that in the control group ( P<0.05 ) .Conclusion Panzaihuang can accelerate the healing of the recurrent aphthous ulcer , decrease the risk of recurrence without increase obvious adverse reaction .
