中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2015年
10期
777-779
,共3页
铝镁加%兰索拉唑%重型颅脑损伤%应激性溃疡%疗效
鋁鎂加%蘭索拉唑%重型顱腦損傷%應激性潰瘍%療效
려미가%란색랍서%중형로뇌손상%응격성궤양%료효
almagate%lansoprazole%heavy craniocerebral injury%stress ulcer%efficacy
目的：评价铝镁加联合兰索拉唑治疗重型颅脑损伤应激性溃疡的临床疗效及安全性。方法60例重型颅脑损伤应激性溃疡患者随机分为试验组28例和对照组32例。2组均实施常规对症治疗，给予脱水、激素等积极性治疗，维持电解质及酸碱平衡，并给予适当的营养支持。对照组静脉滴注兰索拉唑30 mg+0.9％氯化钠注射液100 mL，每日2次；试验组在对照组治疗的基础上加用铝镁加1.5 g（15 mL），鼻饲，每日3次，2组疗程均为7 d。观察2组患者临床疗效、胃酸变化及服药期间不良反应发生率。结果试验组总有效率为82.1％，对照组为71.8％，2组差异无统计学意义（ P＞0.05）。治疗后，2组患者胃酸pH值均较治疗前显著升高（ P＜0.05）；治疗后6 h开始，试验组胃酸pH显著高于对照组（ P＜0.05）。2组用药期间未见明显不良反应。结论铝镁加联合兰索拉唑治疗重型颅脑损伤应激性溃疡可迅速升高患者胃酸pH值，临床疗效确切，无明显不良反应。
目的：評價鋁鎂加聯閤蘭索拉唑治療重型顱腦損傷應激性潰瘍的臨床療效及安全性。方法60例重型顱腦損傷應激性潰瘍患者隨機分為試驗組28例和對照組32例。2組均實施常規對癥治療，給予脫水、激素等積極性治療，維持電解質及痠堿平衡，併給予適噹的營養支持。對照組靜脈滴註蘭索拉唑30 mg+0.9％氯化鈉註射液100 mL，每日2次；試驗組在對照組治療的基礎上加用鋁鎂加1.5 g（15 mL），鼻飼，每日3次，2組療程均為7 d。觀察2組患者臨床療效、胃痠變化及服藥期間不良反應髮生率。結果試驗組總有效率為82.1％，對照組為71.8％，2組差異無統計學意義（ P＞0.05）。治療後，2組患者胃痠pH值均較治療前顯著升高（ P＜0.05）；治療後6 h開始，試驗組胃痠pH顯著高于對照組（ P＜0.05）。2組用藥期間未見明顯不良反應。結論鋁鎂加聯閤蘭索拉唑治療重型顱腦損傷應激性潰瘍可迅速升高患者胃痠pH值，臨床療效確切，無明顯不良反應。
목적：평개려미가연합란색랍서치료중형로뇌손상응격성궤양적림상료효급안전성。방법60례중형로뇌손상응격성궤양환자수궤분위시험조28례화대조조32례。2조균실시상규대증치료，급여탈수、격소등적겁성치료，유지전해질급산감평형，병급여괄당적영양지지。대조조정맥적주란색랍서30 mg+0.9％록화납주사액100 mL，매일2차；시험조재대조조치료적기출상가용려미가1.5 g（15 mL），비사，매일3차，2조료정균위7 d。관찰2조환자림상료효、위산변화급복약기간불량반응발생솔。결과시험조총유효솔위82.1％，대조조위71.8％，2조차이무통계학의의（ P＞0.05）。치료후，2조환자위산pH치균교치료전현저승고（ P＜0.05）；치료후6 h개시，시험조위산pH현저고우대조조（ P＜0.05）。2조용약기간미견명현불량반응。결론려미가연합란색랍서치료중형로뇌손상응격성궤양가신속승고환자위산pH치，림상료효학절，무명현불량반응。
Objective To evaluate the clinical efficacy and safety of almagate combined with lansoprazole in the treatment of stress ulcer patients with heavy craniocerebral injury .Methods A total of 60 stress ulcer patients with heavy craniocerebral injury were included in this study and were divided into experiment group ( n=28 ) and control group ( n=32).Patients in two groups all received regular treatment and nutrition such as dehydration and hormone to maintain electrolyte and acid -base balance.The patients in control group were treated with lansoprazole 30 mg+0.9%NaCl 100 mL by intravenous drip.Patients in the experiment group were given lansoprazole and almagate 1.5 mL by nasal feeding , tid.The course of the two groups were 7 days.The data of total efficacy , gastric acid pH and adverse drug reactions were compared between the two groups.Results The total efficacy were 82.1%and 71.8%in the experiment and control group , respectively , which showed no statistical difference ( P >0.05 ) . The pH of gastric acid after treatment was significantly higer than that before treatment ( P <0.05 ) .The pH of gastric acid was significantly different 6 hours after treatment between the two groups ( P<0.05 ) .No obvious adverse drug reaction was observed in the two groups in the period of treatment .Conclusion Almagate combined with lansoprazole is effective and safe in the treatment of stress ulcer patients with heavy craniocerebral injury.
