中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2015年
10期
771-773
,共3页
李华浚%陈啸洪%章杭湖%董长丰
李華浚%陳嘯洪%章杭湖%董長豐
리화준%진소홍%장항호%동장봉
甲泼尼龙%阿奇霉素%儿童%支原体肺炎%临床疗效
甲潑尼龍%阿奇黴素%兒童%支原體肺炎%臨床療效
갑발니룡%아기매소%인동%지원체폐염%림상료효
methylprednisolone%azithromycin%children%mycoplasma pneumonia%clinical efficacy
目的：评价阿奇霉素联合甲泼尼龙治疗肺炎支原体肺炎患儿的临床疗效及安全性。方法入选肺炎支原体肺炎患儿80例，并随机分为试验组和对照组，各40例。对照组静脉滴注阿奇霉素10 mg? kg-1，qd，共7 d。试验组在对照组用药的基础上静脉滴注甲泼尼龙2 mg? kg-1，bid，患儿体温恢复正常后，改为口服泼尼松片1 mg? kg-1，qd，共5 d。观察2组患儿的临床疗效、咳嗽消失时间、退热时间及住院时间及不良反应发生率。结果试验组和对照组患儿总有效率分别为90.0％和80.0％，差异无统计学意义（ P＞0.05）。试验组患儿的咳嗽消失时间、退热时间及住院时间分别为（4.21±1.55），（8.37±2.13），（11.21±2.65）d，显著低于对照组的（5.19±1.36），（11.99±1.25），（15.25±3.22） d （均P＜0.05）。2组患儿恶心、呕吐发生率分别为17.5％和12.5％，差异无统计学意义（ P＞0.05）。结论阿奇霉素联合甲泼尼龙治疗肺炎支原体肺炎患儿可迅速缓解患儿的临床症状，且不增加不良反应发生率。
目的：評價阿奇黴素聯閤甲潑尼龍治療肺炎支原體肺炎患兒的臨床療效及安全性。方法入選肺炎支原體肺炎患兒80例，併隨機分為試驗組和對照組，各40例。對照組靜脈滴註阿奇黴素10 mg? kg-1，qd，共7 d。試驗組在對照組用藥的基礎上靜脈滴註甲潑尼龍2 mg? kg-1，bid，患兒體溫恢複正常後，改為口服潑尼鬆片1 mg? kg-1，qd，共5 d。觀察2組患兒的臨床療效、咳嗽消失時間、退熱時間及住院時間及不良反應髮生率。結果試驗組和對照組患兒總有效率分彆為90.0％和80.0％，差異無統計學意義（ P＞0.05）。試驗組患兒的咳嗽消失時間、退熱時間及住院時間分彆為（4.21±1.55），（8.37±2.13），（11.21±2.65）d，顯著低于對照組的（5.19±1.36），（11.99±1.25），（15.25±3.22） d （均P＜0.05）。2組患兒噁心、嘔吐髮生率分彆為17.5％和12.5％，差異無統計學意義（ P＞0.05）。結論阿奇黴素聯閤甲潑尼龍治療肺炎支原體肺炎患兒可迅速緩解患兒的臨床癥狀，且不增加不良反應髮生率。
목적：평개아기매소연합갑발니룡치료폐염지원체폐염환인적림상료효급안전성。방법입선폐염지원체폐염환인80례，병수궤분위시험조화대조조，각40례。대조조정맥적주아기매소10 mg? kg-1，qd，공7 d。시험조재대조조용약적기출상정맥적주갑발니룡2 mg? kg-1，bid，환인체온회복정상후，개위구복발니송편1 mg? kg-1，qd，공5 d。관찰2조환인적림상료효、해수소실시간、퇴열시간급주원시간급불량반응발생솔。결과시험조화대조조환인총유효솔분별위90.0％화80.0％，차이무통계학의의（ P＞0.05）。시험조환인적해수소실시간、퇴열시간급주원시간분별위（4.21±1.55），（8.37±2.13），（11.21±2.65）d，현저저우대조조적（5.19±1.36），（11.99±1.25），（15.25±3.22） d （균P＜0.05）。2조환인악심、구토발생솔분별위17.5％화12.5％，차이무통계학의의（ P＞0.05）。결론아기매소연합갑발니룡치료폐염지원체폐염환인가신속완해환인적림상증상，차불증가불량반응발생솔。
Objective To investigate the clinical effects and adverse reactions of methylprednisolone combined with azithromycin for the treat-ment of mycoplasma pneumonia .Methods A total of 80 children with mycoplasma pneumonia were recruited and randomized divided into treat-ment and control group , with 40 cases in each group.Children in the control group were given azithromycin 10 mg? kg -1 through intravenous infusion , qd for 7 days.Children in the treatment group were given met-hylprednisolone 2 mg? kg -1 through intravenous infusion bid combined with azithromycin , and after the temperature returned to normal condi-tion, children were given prednisone tablet 1 mg? kg -1 for 5 days.The data of clinical efficacy , time that symptoms disappeared and adverse drug reactions between the two groups were compared .Results The total clinical efficacy were 90.0%and 80.0%in the treatment and con-trol group , respectively , indicating no statistical difference between the two groups ( P<0.05 );but the symptoms were much shorter than those in control group, such as cough [(4.21 ±1.55) vs (5.19 ±1.36)d], fever [ ( 8.37 ±2.13 ) vs ( 11.99 ±1.25 ) d ] and hospital stay [ ( 11.21 ±2.65 ) vs ( 15.25 ±3.22 ) d ] ( P <0.05 ) .There was no significant difference in adverse drug reactions ( 17.5% vs 12.5%) between the two groups ( P>0.05 ) .Conclusion Methylprednisolone combined with azithromycin can quickly im-prove the symptoms in children with mycoplasma pneumonia , without increasing adverse drug reactions .
