CAJ | 학술논문

目的：探讨尿 N‐乙酰β‐D‐氨基葡萄糖酐酶（NAG）、视黄醇结合蛋白（RBP）、转铁蛋白（TRF）、α1‐微球蛋白（α1‐MG）水平变化对2型糖尿病肾病早期诊断、预测及病情监测的临床应用价值。方法83例2型糖尿病（T2DM ）患者根据尿清蛋白排泄率（UAER）的测定结果，将糖尿病患者分为 UAER 正常组、早期糖尿病肾病组、临床糖尿病肾病组，另选该院体检健康者28例纳入健康对照组。比较4组尿 NAG 、RBP 、TRF 、α1‐MG 水平。结果 UAER 正常组、早期糖尿病肾病组、临床糖尿病肾病组患者NAG 、RBP 、TRF 和α1‐MG 水平明显高于健康对照组，差异有统计学意义（P＜0．05）；早期糖尿病肾病组和临床糖尿病肾病组各项指标均明显高于 UAER 正常组，差异均有统计学意义（P ＜0．05）；临床糖尿病肾病组检出各项指标阳性率最高，NAG 、RBP 、TRF 、α1‐MG 阳性率分别为64．0％、52．0％、72．0％、76．0％；4项指标联合检测在早期糖尿病肾病组和临床糖尿病肾病组均达到较高阳性率，分别为80．0％和96．0％。结论联合检测 NAG 、RBP 、TRF 和α1‐MG 在2型糖尿病肾病患者的早期诊断中有较高的阳性检出率，可作为糖尿病肾病的早期诊断依据。
목적：탐토뇨 N‐을선β‐D‐안기포도당항매（NAG）、시황순결합단백（RBP）、전철단백（TRF）、α1‐미구단백（α1‐MG）수평변화대2형당뇨병신병조기진단、예측급병정감측적림상응용개치。방법83례2형당뇨병（T2DM ）환자근거뇨청단백배설솔（UAER）적측정결과，장당뇨병환자분위 UAER 정상조、조기당뇨병신병조、림상당뇨병신병조，령선해원체검건강자28례납입건강대조조。비교4조뇨 NAG 、RBP 、TRF 、α1‐MG 수평。결과 UAER 정상조、조기당뇨병신병조、림상당뇨병신병조환자NAG 、RBP 、TRF 화α1‐MG 수평명현고우건강대조조，차이유통계학의의（P＜0．05）；조기당뇨병신병조화림상당뇨병신병조각항지표균명현고우 UAER 정상조，차이균유통계학의의（P ＜0．05）；림상당뇨병신병조검출각항지표양성솔최고，NAG 、RBP 、TRF 、α1‐MG 양성솔분별위64．0％、52．0％、72．0％、76．0％；4항지표연합검측재조기당뇨병신병조화림상당뇨병신병조균체도교고양성솔，분별위80．0％화96．0％。결론연합검측 NAG 、RBP 、TRF 화α1‐MG 재2형당뇨병신병환자적조기진단중유교고적양성검출솔，가작위당뇨병신병적조기진단의거。
Objective To explore the clinical application value of the changes in the levels of urine N‐acetyl‐β‐D‐glucosaminidase (NAG) ,retinol binding protein (RBP) ,transferring (TRF) ,and α1‐microglobulin (α1‐MG) for early diagnosis ,forecast and illness monitoring of type 2 diabetes mellitus (T2DM ) .Methods According to test result of urinary albumin excretion rate(UAER) ,83 patients suffering from T2DM were divided into normal UAER group ,early diabetic nephropathy group and clinical diabetic ne‐phropathy group ,meanwhile ,28 healthy persons were selected into the healthy control group ,the levels of NAG ,RBP ,TRF ,and α1‐MG were compared in the four groups .Results The levels of NAG ,RBP ,TRF ,and α1‐MG in the normal UAER group ,early dia‐betic nephropathy group and clinical diabetic nephropathy group were significant higher than the control group ,the differences were significant (P< 0 .05) .The four indicators in the early diabetic nephropathy group and clinical diabetic nephropathy group were sig‐nificant higher than those of the normal UAER group ,their differences were statistical significant (P< 0 .05) .In the clinical diabetic nephropathy group ,the positive rates of the indicators were highest ,with NAG 64 .0% ,RBP 52 .0% ,TRF 72 .0% and α1‐MG 76 .0% .For both the early diabetic nephropathy group and clinical diabetic nephropathy group ,the positive rates in the combined detection of four items were relatively high ,reaching 80 .0% and 96 .0% .Conclusion The combined detection of NAG ,RBP ,TRF , and α1‐MG showed relatively high positive rates ,could be taken as the basis for the early diagnosis of diabetic nephropathy .