CAJ | 학술논문

目的：探讨糖化血红蛋白（HbA1c）测定对糖尿病诊疗和并发症风险预测的临床应用价值。方法160例糖尿病患者纳入糖尿病组，按照有无糖尿病并发症分为并发症亚组（88例）和无并发症亚组（72例）。同期158例体检无糖尿病者纳入对照组。罗氏 cobas C501全自动生化分析仪检测所有被试 HbA1c 及空腹血糖（FBG ）水平并进行比较。结果糖尿病组患者HbA1c 、FBG 水平明显高于对照组，差异均有统计学意义（P ＜0．05）。并发症亚组患者 HbA1c 、FBG 水平明显高于无并发症亚组，差异均有统计学意义（P ＜0．05）。糖尿病组 HbA1c 异常升高率明显高于对照组，差异有统计学意义（P ＜0．05）。结论HbA1c 可用于糖尿病的早期诊断、筛查、鉴别诊断、治疗监测和预测评价糖尿病并发症风险，也可将 HbA1c 检测作为健康体检的常规检查项目之一。
목적：탐토당화혈홍단백（HbA1c）측정대당뇨병진료화병발증풍험예측적림상응용개치。방법160례당뇨병환자납입당뇨병조，안조유무당뇨병병발증분위병발증아조（88례）화무병발증아조（72례）。동기158례체검무당뇨병자납입대조조。라씨 cobas C501전자동생화분석의검측소유피시 HbA1c 급공복혈당（FBG ）수평병진행비교。결과당뇨병조환자HbA1c 、FBG 수평명현고우대조조，차이균유통계학의의（P ＜0．05）。병발증아조환자 HbA1c 、FBG 수평명현고우무병발증아조，차이균유통계학의의（P ＜0．05）。당뇨병조 HbA1c 이상승고솔명현고우대조조，차이유통계학의의（P ＜0．05）。결론HbA1c 가용우당뇨병적조기진단、사사、감별진단、치료감측화예측평개당뇨병병발증풍험，야가장 HbA1c 검측작위건강체검적상규검사항목지일。
Objective To investigate the clinical value of glycosylated hemoglobin(HbA1c) in diagnosis treatment and risk of complications forecast .Methods A total of 160 diabetes mellitus patients were recruited into diabetes mellitus group ,and divided into complication subgroup(88 cases)and non complication subgroup(72 cases) .Other 158 persons without diabetic were selected into control group .The levels of HbA1c and fasting blood‐glucose(FBG) were detected by Roche cobas C501 fully automatic bio‐chemical analyzer and compared .Results The levels of HbA1c and FBG in the diabetes mellitus group were significant higher than those of the control group ,the differences were statistical significant (P< 0 .05) .The levels of HbA1c and FBG in the complication subgroup were significant higher than those of the non complication group ,the differences were statistical significant (P < 0 .05) . The positive rate of HbA1c in the diabetes mellitus group was significant higher than that of the control group ,the difference was statistical significant (P< 0 .05) .Conclusion HbA1c could be used for the early diagnosis ,screening ,differential diagnosis ,treat‐ment monitoring and evaluation of the risk of complications of diabetes mellitus ,and also could be used as one of the routine physical examination .