国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
11期
1580-1581,1583
,共3页
动脉粥样硬化%超敏 C 反应蛋白%同型半胱氨酸%D-二聚体
動脈粥樣硬化%超敏 C 反應蛋白%同型半胱氨痠%D-二聚體
동맥죽양경화%초민 C 반응단백%동형반광안산%D-이취체
atherosclerosis%high sensitivity C-reactive protein%homocysteine%D-dimer
目的:分析超敏 C 反应蛋白(hs‐CRP)、同型半胱氨酸(Hcy)、D‐二聚体(D‐D)水平与动脉粥样硬化(AS)发展变化的关系及意义。方法回顾性分析92例 AS 患者,其中急性冠状动脉综合征(ACS)组61例,稳定型心绞痛(SAP)组31例;并根据CT 检测的冠状动脉斑块结果将92例 AS 患者进一步分为斑块组、无斑块组,稳定斑块亚组、不稳定斑块亚组;另外选择42例体检健康者纳入对照组。比较各组3项指标水平。结果 SAP 组和 ACS 组血中 hs‐CRP 、D‐D 、Hcy 水平均明显高于对照组,ACS组血中 hs‐CRP 、D‐D 、Hcy 水平均明显高于 SAP 组,差异均有统计学意义(P<0.05)。斑块组 hs‐CRP 、D‐D 、Hcy 水平均明显高于无斑块组,不稳定斑块亚组明显高于稳定斑块亚组,差异均有统计学意义(P<0.05)。 ACS 患者3项指标水平均呈正相关(P<0.05)。结论血清 hs‐CRP 、Hcy 和血浆 D‐D 浓度与 AS 的发生、发展密切相关,3项指标联合检测对 AS 的预防、治疗和预后均有重要临床意义。
目的:分析超敏 C 反應蛋白(hs‐CRP)、同型半胱氨痠(Hcy)、D‐二聚體(D‐D)水平與動脈粥樣硬化(AS)髮展變化的關繫及意義。方法迴顧性分析92例 AS 患者,其中急性冠狀動脈綜閤徵(ACS)組61例,穩定型心絞痛(SAP)組31例;併根據CT 檢測的冠狀動脈斑塊結果將92例 AS 患者進一步分為斑塊組、無斑塊組,穩定斑塊亞組、不穩定斑塊亞組;另外選擇42例體檢健康者納入對照組。比較各組3項指標水平。結果 SAP 組和 ACS 組血中 hs‐CRP 、D‐D 、Hcy 水平均明顯高于對照組,ACS組血中 hs‐CRP 、D‐D 、Hcy 水平均明顯高于 SAP 組,差異均有統計學意義(P<0.05)。斑塊組 hs‐CRP 、D‐D 、Hcy 水平均明顯高于無斑塊組,不穩定斑塊亞組明顯高于穩定斑塊亞組,差異均有統計學意義(P<0.05)。 ACS 患者3項指標水平均呈正相關(P<0.05)。結論血清 hs‐CRP 、Hcy 和血漿 D‐D 濃度與 AS 的髮生、髮展密切相關,3項指標聯閤檢測對 AS 的預防、治療和預後均有重要臨床意義。
목적:분석초민 C 반응단백(hs‐CRP)、동형반광안산(Hcy)、D‐이취체(D‐D)수평여동맥죽양경화(AS)발전변화적관계급의의。방법회고성분석92례 AS 환자,기중급성관상동맥종합정(ACS)조61례,은정형심교통(SAP)조31례;병근거CT 검측적관상동맥반괴결과장92례 AS 환자진일보분위반괴조、무반괴조,은정반괴아조、불은정반괴아조;령외선택42례체검건강자납입대조조。비교각조3항지표수평。결과 SAP 조화 ACS 조혈중 hs‐CRP 、D‐D 、Hcy 수평균명현고우대조조,ACS조혈중 hs‐CRP 、D‐D 、Hcy 수평균명현고우 SAP 조,차이균유통계학의의(P<0.05)。반괴조 hs‐CRP 、D‐D 、Hcy 수평균명현고우무반괴조,불은정반괴아조명현고우은정반괴아조,차이균유통계학의의(P<0.05)。 ACS 환자3항지표수평균정정상관(P<0.05)。결론혈청 hs‐CRP 、Hcy 화혈장 D‐D 농도여 AS 적발생、발전밀절상관,3항지표연합검측대 AS 적예방、치료화예후균유중요림상의의。
Objective Analyze the relationship between high sensitivity C‐reactive protein (hs‐CRP) ,homocysteine (Hcy) ,D‐di‐mer (D‐D) levels and atherosclerosis (AS) .Methods A total of 92 patients with AS were analyzed retrospectively ,including acute coronary syndrome (ACS) group with 61 cases ,stable angina pectoris (SAP) group with 31 cases .According to the result of coro‐nary artery plaque CT detection was further divided into plaque group ,non plaque group ,stable plaque subgroup ,and unstable plaque subgroup .Meanwhile 42 healthy subjects were selected as control group .The levels of the three indicators were compared . Results The serum hs‐CRP ,Hcy and plasma D‐D concentration in the ACS group and SAP group were significant higher than those of the control group (P< 0 .05) ,and those of the ACS group were significant higher than those of the SAP group(P< 0 .05) . The serum hs‐CRP ,Hcy and plasma D‐D concentration in the plaque group were significant higher than those of the non plaque group ,those in the unstable plaque subgroup were significant higher than those of the stable plaque subgroup(P< 0 .05) .The serum hs‐CRP ,Hcy and plasma D‐D concentration of the ACS patients were all correlated positively .Conclusion Serum hs‐CRP ,Hcy and plasma D‐D levels are closely related to the development of AS ,the combined detection of three indexes is value for the prevention , treatment and prognosis of AS .