CAJ | 학술논문

目的：分析超敏 C 反应蛋白（hs‐CRP）、同型半胱氨酸（Hcy）、D‐二聚体（D‐D）水平与动脉粥样硬化（AS）发展变化的关系及意义。方法回顾性分析92例 AS 患者，其中急性冠状动脉综合征（ACS）组61例，稳定型心绞痛（SAP）组31例；并根据CT 检测的冠状动脉斑块结果将92例 AS 患者进一步分为斑块组、无斑块组，稳定斑块亚组、不稳定斑块亚组；另外选择42例体检健康者纳入对照组。比较各组3项指标水平。结果 SAP 组和 ACS 组血中 hs‐CRP 、D‐D 、Hcy 水平均明显高于对照组，ACS组血中 hs‐CRP 、D‐D 、Hcy 水平均明显高于 SAP 组，差异均有统计学意义（P＜0．05）。斑块组 hs‐CRP 、D‐D 、Hcy 水平均明显高于无斑块组，不稳定斑块亚组明显高于稳定斑块亚组，差异均有统计学意义（P＜0．05）。 ACS 患者3项指标水平均呈正相关（P＜0．05）。结论血清 hs‐CRP 、Hcy 和血浆 D‐D 浓度与 AS 的发生、发展密切相关，3项指标联合检测对 AS 的预防、治疗和预后均有重要临床意义。
목적：분석초민 C 반응단백（hs‐CRP）、동형반광안산（Hcy）、D‐이취체（D‐D）수평여동맥죽양경화（AS）발전변화적관계급의의。방법회고성분석92례 AS 환자，기중급성관상동맥종합정（ACS）조61례，은정형심교통（SAP）조31례；병근거CT 검측적관상동맥반괴결과장92례 AS 환자진일보분위반괴조、무반괴조，은정반괴아조、불은정반괴아조；령외선택42례체검건강자납입대조조。비교각조3항지표수평。결과 SAP 조화 ACS 조혈중 hs‐CRP 、D‐D 、Hcy 수평균명현고우대조조，ACS조혈중 hs‐CRP 、D‐D 、Hcy 수평균명현고우 SAP 조，차이균유통계학의의（P＜0．05）。반괴조 hs‐CRP 、D‐D 、Hcy 수평균명현고우무반괴조，불은정반괴아조명현고우은정반괴아조，차이균유통계학의의（P＜0．05）。 ACS 환자3항지표수평균정정상관（P＜0．05）。결론혈청 hs‐CRP 、Hcy 화혈장 D‐D 농도여 AS 적발생、발전밀절상관，3항지표연합검측대 AS 적예방、치료화예후균유중요림상의의。
Objective Analyze the relationship between high sensitivity C‐reactive protein (hs‐CRP) ,homocysteine (Hcy) ,D‐di‐mer (D‐D) levels and atherosclerosis (AS) .Methods A total of 92 patients with AS were analyzed retrospectively ,including acute coronary syndrome (ACS) group with 61 cases ,stable angina pectoris (SAP) group with 31 cases .According to the result of coro‐nary artery plaque CT detection was further divided into plaque group ,non plaque group ,stable plaque subgroup ,and unstable plaque subgroup .Meanwhile 42 healthy subjects were selected as control group .The levels of the three indicators were compared . Results The serum hs‐CRP ,Hcy and plasma D‐D concentration in the ACS group and SAP group were significant higher than those of the control group (P< 0 .05) ,and those of the ACS group were significant higher than those of the SAP group(P< 0 .05) . The serum hs‐CRP ,Hcy and plasma D‐D concentration in the plaque group were significant higher than those of the non plaque group ,those in the unstable plaque subgroup were significant higher than those of the stable plaque subgroup(P< 0 .05) .The serum hs‐CRP ,Hcy and plasma D‐D concentration of the ACS patients were all correlated positively .Conclusion Serum hs‐CRP ,Hcy and plasma D‐D levels are closely related to the development of AS ,the combined detection of three indexes is value for the prevention , treatment and prognosis of AS .