国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
11期
1525-1527
,共3页
王广洲%韩东升%汤惠%周林
王廣洲%韓東升%湯惠%週林
왕엄주%한동승%탕혜%주림
医院感染%耐碳青霉烯鲍曼不动杆菌%耐甲氧西林金黄色葡萄球菌
醫院感染%耐碳青黴烯鮑曼不動桿菌%耐甲氧西林金黃色葡萄毬菌
의원감염%내탄청매희포만불동간균%내갑양서림금황색포도구균
hospital infection%carbapenem-resistant Acinetobacter baumannii%methicillin-resistant Staphylococcus aureus
目的:了解该院医院感染致病原中耐碳青霉烯鲍曼不动杆菌(CR‐AB)和耐甲氧西林金黄色葡萄球菌(MRSA )的临床分布特征和耐药现状,合理指导临床使用抗菌药物。方法回顾性分析2011年1月至2014年3月该院住院患者 CR‐AB 和MRSA 的医院感染情况,利用纸片扩散法对收集的菌株进行药敏试验。结果共检出 CR‐AB 170株,主要分布在 ICU 病房,占61.17%(104/170);MRSA 168株,主要分布在神经外科,占27.98%(47/168)。痰液是 CR‐AB 和 MRSA 最主要的标本来源,分别占67.06%和54.17%。 CR‐AB 对多数抗菌药物的耐药率均达到50.00%以上,但对头孢派酮/舒巴坦(27.65%)、米诺环素(21.18%)、丁胺卡那霉素(19.41%)和妥布霉素(12.35%)耐药率低于30.00%,未发现耐多黏菌素的菌株;MRSA 对利奈唑烷、万古霉素和替加环素100.00%敏感,对呋喃妥因和奎努普汀/达福普汀的耐药性也较低(<2.00%)。结论 CR‐AB 和 MRSA 的耐药性较为严重,应加强对重点感染病房的管理,合理选择抗菌药物,以防止 CR‐AB 和 MRSA 等多重耐药菌株的传播。
目的:瞭解該院醫院感染緻病原中耐碳青黴烯鮑曼不動桿菌(CR‐AB)和耐甲氧西林金黃色葡萄毬菌(MRSA )的臨床分佈特徵和耐藥現狀,閤理指導臨床使用抗菌藥物。方法迴顧性分析2011年1月至2014年3月該院住院患者 CR‐AB 和MRSA 的醫院感染情況,利用紙片擴散法對收集的菌株進行藥敏試驗。結果共檢齣 CR‐AB 170株,主要分佈在 ICU 病房,佔61.17%(104/170);MRSA 168株,主要分佈在神經外科,佔27.98%(47/168)。痰液是 CR‐AB 和 MRSA 最主要的標本來源,分彆佔67.06%和54.17%。 CR‐AB 對多數抗菌藥物的耐藥率均達到50.00%以上,但對頭孢派酮/舒巴坦(27.65%)、米諾環素(21.18%)、丁胺卡那黴素(19.41%)和妥佈黴素(12.35%)耐藥率低于30.00%,未髮現耐多黏菌素的菌株;MRSA 對利奈唑烷、萬古黴素和替加環素100.00%敏感,對呋喃妥因和奎努普汀/達福普汀的耐藥性也較低(<2.00%)。結論 CR‐AB 和 MRSA 的耐藥性較為嚴重,應加彊對重點感染病房的管理,閤理選擇抗菌藥物,以防止 CR‐AB 和 MRSA 等多重耐藥菌株的傳播。
목적:료해해원의원감염치병원중내탄청매희포만불동간균(CR‐AB)화내갑양서림금황색포도구균(MRSA )적림상분포특정화내약현상,합리지도림상사용항균약물。방법회고성분석2011년1월지2014년3월해원주원환자 CR‐AB 화MRSA 적의원감염정황,이용지편확산법대수집적균주진행약민시험。결과공검출 CR‐AB 170주,주요분포재 ICU 병방,점61.17%(104/170);MRSA 168주,주요분포재신경외과,점27.98%(47/168)。담액시 CR‐AB 화 MRSA 최주요적표본래원,분별점67.06%화54.17%。 CR‐AB 대다수항균약물적내약솔균체도50.00%이상,단대두포파동/서파탄(27.65%)、미낙배소(21.18%)、정알잡나매소(19.41%)화타포매소(12.35%)내약솔저우30.00%,미발현내다점균소적균주;MRSA 대리내서완、만고매소화체가배소100.00%민감,대부남타인화규노보정/체복보정적내약성야교저(<2.00%)。결론 CR‐AB 화 MRSA 적내약성교위엄중,응가강대중점감염병방적관리,합리선택항균약물,이방지 CR‐AB 화 MRSA 등다중내약균주적전파。
Objective To provide a scientific reference for the choice of antimicrobial drugs by analyzing the distributions and the antimicrobial resistances of Carbapenem‐resistant Acinetobacter baumannii (CR‐AB) and methicillin‐resistant Staphylococcus au‐reus (MRSA) in the Northern Jiangsu People′s Hospital .Methods All the CR‐AB and the MRSA isolated from hospitalized pa‐tients from January 2011 to March 2014 were collected and analyzed .Use the disk diffusion method for antimicrobial resistance tes‐ting .Results A total of 170 CR‐AB strains and 168 MRSA strains were isolated .CR‐AB mainly distributed in the ICU ,which ac‐counting for 61 .17% (104/170) .MRSA mainly isolated in neurosurgery ,about 27 .98% (47/168) .67 .06% of CR‐AB strains and 54 .17% of MRSA strains were from Sputum specimens .The antimicrobial resistance rate of CR‐AB to most antimicrobial drugs were reached 50 .00% ,the resistance rates to cefoperazone/sulbactam (27 .65% ) ,minocycline (21 .18% ) ,amikacin (19 .41% ) and tobramycin (12 .35% ) were all less than 30 .00% ,the strain that resistant to polymyxin was not found .The sensitivity rates of MR‐SA to linezolid ,vancomycin ,and tigecycline were 100 .00% ,and the resistance rates to nitrofurantoin and kuinuputing/ dalfopristin were low (less than 2 .00% ) .Conclusion The antimicrobial resistances of CR‐AB and MRSA are serious .In order to control effec‐tively the spreading of CR‐AB ,MRSA and other multi‐drug resistant bacteria ,it′s necessary for us to strengthen the management of key departments ,and select antimicrobial drugs based on the results of drug susceptibility testing .