国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
11期
1533-1534
,共2页
柏淑美%郭绪晓%刘礼青%冯慧
柏淑美%郭緒曉%劉禮青%馮慧
백숙미%곽서효%류례청%풍혜
D-二聚体%心肌肌钙蛋白I%血清N末端B型钠尿肽原%慢性阻塞性肺疾病
D-二聚體%心肌肌鈣蛋白I%血清N末耑B型鈉尿肽原%慢性阻塞性肺疾病
D-이취체%심기기개단백I%혈청N말단B형납뇨태원%만성조새성폐질병
D-dimer%cardiac troponin I%N terminal b-type natriuretic peptide%chronic obstructive pulmonary disease
目的:探讨 D‐二聚体、心肌肌钙蛋白 I(cTnI)和血清 N 末端 B 型钠尿肽原(NT‐proBNP)在慢性阻塞性肺疾病(COPD)急性加重期及治疗缓解期的浓度变化及临床意义。方法检测40例 COPD 患者急性加重期及治疗缓解期 D‐二聚体、cTnI 和 NT‐proBNP 水平,同期选择体检健康者40例纳入对照组,检测3项指标水平并进行比较。结果 COPD 急性加重期 D‐二聚体、cTnI 、NT‐proBNP 水平分别为(1.83±1.14)μg/mL 、(1.16±0.60)ng/mL 和(819.62±172.37)pg/mL ,均明显高于缓解期患者的(0.53±0.24)μg/mL 、(0.55±0.12)ng /mL 和(250.80±79.90)pg/mL ,差异均有统计学意义(P<0.05)。 COPD 缓解期D‐二聚体、cTnI 和 NT‐proBNP 水平均高于对照组的(0.22±0.10)μg/mL 、(0.13±0.05)ng/mL 和(85.81±31.13)pg /mL ,差异均有统计学意义(P<0.05)。结论 D‐二聚体、cTnI 和 NT‐proBNP 水平在 COPD 患者中明显升高,其联合检测对于 COPD 的诊断、进展及治疗具有重要的临床指导意义。
目的:探討 D‐二聚體、心肌肌鈣蛋白 I(cTnI)和血清 N 末耑 B 型鈉尿肽原(NT‐proBNP)在慢性阻塞性肺疾病(COPD)急性加重期及治療緩解期的濃度變化及臨床意義。方法檢測40例 COPD 患者急性加重期及治療緩解期 D‐二聚體、cTnI 和 NT‐proBNP 水平,同期選擇體檢健康者40例納入對照組,檢測3項指標水平併進行比較。結果 COPD 急性加重期 D‐二聚體、cTnI 、NT‐proBNP 水平分彆為(1.83±1.14)μg/mL 、(1.16±0.60)ng/mL 和(819.62±172.37)pg/mL ,均明顯高于緩解期患者的(0.53±0.24)μg/mL 、(0.55±0.12)ng /mL 和(250.80±79.90)pg/mL ,差異均有統計學意義(P<0.05)。 COPD 緩解期D‐二聚體、cTnI 和 NT‐proBNP 水平均高于對照組的(0.22±0.10)μg/mL 、(0.13±0.05)ng/mL 和(85.81±31.13)pg /mL ,差異均有統計學意義(P<0.05)。結論 D‐二聚體、cTnI 和 NT‐proBNP 水平在 COPD 患者中明顯升高,其聯閤檢測對于 COPD 的診斷、進展及治療具有重要的臨床指導意義。
목적:탐토 D‐이취체、심기기개단백 I(cTnI)화혈청 N 말단 B 형납뇨태원(NT‐proBNP)재만성조새성폐질병(COPD)급성가중기급치료완해기적농도변화급림상의의。방법검측40례 COPD 환자급성가중기급치료완해기 D‐이취체、cTnI 화 NT‐proBNP 수평,동기선택체검건강자40례납입대조조,검측3항지표수평병진행비교。결과 COPD 급성가중기 D‐이취체、cTnI 、NT‐proBNP 수평분별위(1.83±1.14)μg/mL 、(1.16±0.60)ng/mL 화(819.62±172.37)pg/mL ,균명현고우완해기환자적(0.53±0.24)μg/mL 、(0.55±0.12)ng /mL 화(250.80±79.90)pg/mL ,차이균유통계학의의(P<0.05)。 COPD 완해기D‐이취체、cTnI 화 NT‐proBNP 수평균고우대조조적(0.22±0.10)μg/mL 、(0.13±0.05)ng/mL 화(85.81±31.13)pg /mL ,차이균유통계학의의(P<0.05)。결론 D‐이취체、cTnI 화 NT‐proBNP 수평재 COPD 환자중명현승고,기연합검측대우 COPD 적진단、진전급치료구유중요적림상지도의의。
Objective To investigate the changes of cardiac troponin I (cTnI)and N terminal B‐type natriuretic peptide(NT‐proBNP) and their clinical significances in patients with chronic obstructive pulmonary disease(COPD) .Methods D‐dimer 、cTnI and NT‐proBNP levels were measured in 40 patients with COPD at acute exacerbation and remission stage ,and 40 healthy subjects (control gruop)respectively .Results Levels of D‐dimer ,cTnI and NT‐proBNP of COPD patients in the acute exacerbation stage were (1 .83 ± 1 .14)μg/mL 、(1 .16 ± 0 .60)ng/mL 、(819 .62 ± 172 .37 )pg/mL respectively ,which were significant higher than (0 .53 ± 0 .24)μg/mL ,(0 .55 ± 0 .12)ng/mL ,(250 .80 ± 79 .90)pg/mL in remission stage(P< 0 .05) .D‐dimer 、cTnI and NT‐proBNP levels of COPD patients in the remission stage were significant higher than (0 .22 ± 0 .10)μg /mL ,(0 .13 ± 0 .05)ng/mL ,(85 .81 ± 31 .13)pg/mL in the control group (P < 0 .05) .Conclusion The levels of D‐dimer ,cTnI and NT‐proBNP of COPD patients are higher than those of healthy person ,combined detection of D‐dimer ,cTnI and NT‐proBNP could provide clinical significances for di‐agnosis ,development and treatment of COPD .