CAJ | 학술논문

目的：：通过 Lequesne 指数评分，比较早期膝关节骨性关节炎(OA)患者膝关节腔内分别注射透明质酸钠与糖皮质激素复方倍他米松的治疗效果[1]。方法：100例膝骨关节炎患者随机平均分为玻璃酸钠组与激素组，每组各50例。临床评估即 Lequesne 指数评分，评估是分别在第1、3、6个月评测。结果：在第1个月时，两组患者之间 Lequesne 指数评分均明显降低，与治疗前比较具有统计学意义；第3个月开始两组患者评分持续降低，但透明质酸钠组患者的 Lequesne 评分显著低于激素组；第6个月时，两组患者的 Lequesne 评分有回升趋势，数据显示两组中玻璃酸钠组评分回升显著慢于激素组，玻璃酸钠组患者的治疗后效果更为持久。结论：早期 OA 患者关节腔注射透明质酸与激素治疗可明显降低膝关节的 Lequesne 指数评分，但关节腔内注射玻璃酸钠效果更佳。
목적：：통과 Lequesne 지수평분，비교조기슬관절골성관절염(OA)환자슬관절강내분별주사투명질산납여당피질격소복방배타미송적치료효과[1]。방법：100례슬골관절염환자수궤평균분위파리산납조여격소조，매조각50례。림상평고즉 Lequesne 지수평분，평고시분별재제1、3、6개월평측。결과：재제1개월시，량조환자지간 Lequesne 지수평분균명현강저，여치료전비교구유통계학의의；제3개월개시량조환자평분지속강저，단투명질산납조환자적 Lequesne 평분현저저우격소조；제6개월시，량조환자적 Lequesne 평분유회승추세，수거현시량조중파리산납조평분회승현저만우격소조，파리산납조환자적치료후효과경위지구。결론：조기 OA 환자관절강주사투명질산여격소치료가명현강저슬관절적 Lequesne 지수평분，단관절강내주사파리산납효과경가。
Objective: To compare clinical effects of sodium hyaluronate and glucocorticoid in treatment of early knee osteoar-thritis (OA) though Lequesne index score[1] . Methods: 100 patients with osteoarthritis were randomly divided into sodium hyalur-onate group and glucocorticoid group. The clinical assessments (Lequesne index score) were done at 1, 3, and 6 months. Results: At the first month, the Lequesne index scores of the two groups were significantly reduced, and the differences before and after the treat-ment were statistically significant. At the third month, the Lequesne index scores of the two groups continued to decrease; however, the Lequesne index score of sodium hyaluronate group was significantly lower than that of glucocorticoid group. At the sixth month, the two groups showed a rebounding trend of the Lequesne index score, and the data showed that the sodium hyaluronate group score signifi-cantly rebounded slower than that of glucocorticoid group, indicating the therapeutic effect of sodium hyaluronate group was more dura-ble than glucocorticoid group. Conclusions: For the Patients with early OA, sodium hyaluronate and glucocorticoid both can signifi-cantly reduce the Lequesne index score, but the intra-articular injection of sodium hyaluronate has a better therapeutic effect.