中国麻风皮肤病杂志
中國痳風皮膚病雜誌
중국마풍피부병잡지
CHINA JOURNAL OF LEPROSY AND SKIN DISEASES
2015年
6期
347-350
,共4页
麻风%T细胞应答%TCR%CDR3
痳風%T細胞應答%TCR%CDR3
마풍%T세포응답%TCR%CDR3
leprosy%T cell response%TCR%CDR3
麻风的发生、发展及转归与机体免疫系统密切相关,其中T细胞介导的免疫应答发挥了关键性作用。 T细胞通过T细胞受体( TCR)互补决定区CDR3与麻风分枝杆菌抗原结合,产生特异性T细胞免疫效应。测定TCR CDR3谱型分布特征能够反映麻风分枝杆菌感染状态下特定T细胞的扩增程度。本文就麻风T细胞应答及TCR CDR3谱序研究进展作一综述。
痳風的髮生、髮展及轉歸與機體免疫繫統密切相關,其中T細胞介導的免疫應答髮揮瞭關鍵性作用。 T細胞通過T細胞受體( TCR)互補決定區CDR3與痳風分枝桿菌抗原結閤,產生特異性T細胞免疫效應。測定TCR CDR3譜型分佈特徵能夠反映痳風分枝桿菌感染狀態下特定T細胞的擴增程度。本文就痳風T細胞應答及TCR CDR3譜序研究進展作一綜述。
마풍적발생、발전급전귀여궤체면역계통밀절상관,기중T세포개도적면역응답발휘료관건성작용。 T세포통과T세포수체( TCR)호보결정구CDR3여마풍분지간균항원결합,산생특이성T세포면역효응。측정TCR CDR3보형분포특정능구반영마풍분지간균감염상태하특정T세포적확증정도。본문취마풍T세포응답급TCR CDR3보서연구진전작일종술。
Immune system, especially T cell response, plays an important role in the occurrence, develop-ment, and transformation of leprosy. The specific binding of M. leprae antigen and complementarity determi-ning region 3 ( CDR3) of T cell receptor ( TCR) induce the specific T cell response. The feature of TCR CDR3 can reflect the clone degree of specific T cells after infected by M. leprae. The update of T cell re-sponse and TCR CDR3 spectratyping in the patients with leprosy were reviewed in this paper.