CAJ | 학술논문

目的：探讨帕金森病（Parkinson disease,PD）患者的杂乱生物运动感知能力。方法30例原发性PD患者以及与其人口学资料相匹配的正常对照组作为研究对象，采用生物运动的时距辨别任务（a duration dis?crimination task）进行杂乱生物运动感知能力测试。采用Hoehn-Yabr(H-Y)分级量表对PD患者的严重程度进行评定。结果与检验值“0”相比，正常对照组的主观相等点（the point of subjective equality, PSE）（-0.15±0.18）为负值，差异有统计学意义（t=4.56,P<0.001）。PD患者的PSE（0.04±0.21）与正常对照组的PSE相比，负值消失，差异有统计学意义（t=3.72, P<0.001）。PD 患者组按病情严重程度分为2亚组，PD早期组（H-Y 1~2级）的PSE （0.02±0.26）和PD中期组（H-Y 2.5~3级）的PSE（0.06±0.12）与正常对照组相比，差异均有统计学意义（PD早期组：P<0.01；PD中期组：P<0.01）。PD早期组和PD中期组的PSE之间无明显差异(P=0.61)。结论 PD患者在病程的早期即出现杂乱生物运动感知能力障碍，这种感知障碍可能与前额叶功能异常有关。
목적：탐토파금삼병（Parkinson disease,PD）환자적잡란생물운동감지능력。방법30례원발성PD환자이급여기인구학자료상필배적정상대조조작위연구대상，채용생물운동적시거변별임무（a duration dis?crimination task）진행잡란생물운동감지능력측시。채용Hoehn-Yabr(H-Y)분급량표대PD환자적엄중정도진행평정。결과여검험치“0”상비，정상대조조적주관상등점（the point of subjective equality, PSE）（-0.15±0.18）위부치，차이유통계학의의（t=4.56,P<0.001）。PD환자적PSE（0.04±0.21）여정상대조조적PSE상비，부치소실，차이유통계학의의（t=3.72, P<0.001）。PD 환자조안병정엄중정도분위2아조，PD조기조（H-Y 1~2급）적PSE （0.02±0.26）화PD중기조（H-Y 2.5~3급）적PSE（0.06±0.12）여정상대조조상비，차이균유통계학의의（PD조기조：P<0.01；PD중기조：P<0.01）。PD조기조화PD중기조적PSE지간무명현차이(P=0.61)。결론 PD환자재병정적조기즉출현잡란생물운동감지능력장애，저충감지장애가능여전액협공능이상유관。
Objective To explore scrambled biological motion perception in Parkinson’s disease (PD). Meth?ods Thirty individuals with idiopathic PD and matched health controls (HCs) underwent discrimination task.The severi?ty of disease was assessed based on the Hohen and Yahr scale. Results Compared with“PSE=0”,there was a significant negative PSE (the point of subjective equality) (-0.15 ± 0.18) for HCs ( t=4.56, P<0.001), suggesting a temporal dilation effect of the upright scrambled biological motion sequences in HCs. There was a significant difference in the PSE be?tween PD patients(t=3.72,P<0.001) and HCs. Patients in the PD group were then divided into two subgroups accord?ing to their status of disease. There were significant differences in PSE between early-stage PD patients (stage 1-2) (0.02±0.26) and HCs (P<0.01), and between mid-stage PD patients (stage 2.5-3) (0.06±0.12) and HCs (P<0.01). There was no significant difference in PSE between early-stage and mid-stage PD patients (P=0.61). Conclusion The present study suggests that there is a scrambled biological motion perception impairment in PD at the very early stage, which might be attributed to the dysfunction of the prefrontal lobe.