CAJ | 학술논문

目的：探讨单胺氧化酶A串联重复序列（monoamine oxidase A variable nucleotide tandem repeat， MAOA-VNTR）基因型与童年期虐待经历各自及其交互作用对女性青少年冲动特质的影响。方法选取西北某地403名正常汉族女性青少年，完成Barratt冲动量表（Barratt impulsiveness scale，BIS）及童年创伤经历问卷（childhood trauma questionnaire，CTQ），采集其外周静脉血并进行DNA提取及MAOA-VNTR基因分型。采用线性回归分析MAOA-VNTR基因型、童年期虐待经历，以及其交互作用对冲动量表得分的影响。结果童年期虐待经历对女性青少年冲动特质的主效应具有统计学意义（P<0.01），而MAOA-VNTR基因型的主效应，以及MAOA-VNTR与童年虐待经历的交互作用均无统计学意义（均P>0.05）。结论本研究并未发现MAOA-VNTR基因型对童年期虐待所致女性青少年冲动具有调节作用。
목적：탐토단알양화매A천련중복서렬（monoamine oxidase A variable nucleotide tandem repeat， MAOA-VNTR）기인형여동년기학대경력각자급기교호작용대녀성청소년충동특질적영향。방법선취서북모지403명정상한족녀성청소년，완성Barratt충동량표（Barratt impulsiveness scale，BIS）급동년창상경력문권（childhood trauma questionnaire，CTQ），채집기외주정맥혈병진행DNA제취급MAOA-VNTR기인분형。채용선성회귀분석MAOA-VNTR기인형、동년기학대경력，이급기교호작용대충동량표득분적영향。결과동년기학대경력대녀성청소년충동특질적주효응구유통계학의의（P<0.01），이MAOA-VNTR기인형적주효응，이급MAOA-VNTR여동년학대경력적교호작용균무통계학의의（균P>0.05）。결론본연구병미발현MAOA-VNTR기인형대동년기학대소치녀성청소년충동구유조절작용。
Objective To examine the impact on impulsivity trait by monoamine oxidase A variable nucleotide tan?dem repeat (MAOA-VNTR) genotype and children’s abuse experience. Methods The self-reported questionnaire of Bar?ratt Impulsiveness Scale (BIS), Childhood Trauma Questionnaire (CTQ) were conducted in 403 normal Han female adoles?cents from north-west of China. The DNA were extracted from their venous blood sample and were genotyped for the MAOA-VNTR polymorphism. A linear regression model was used to investigate the main effects of MAOA-VNTR and children's abuse, and their interaction effect on impulsivity. Results The main effect of Children’s maltreatment experi?ence on trait impulsivity was significant (P<0.01). The main effect of MAOA-VNTR gene and the interaction between MAOA-VNTR genotype and children's maltreatment experience were insignificant (P>0.05). Conclusion The MAOA-VNTR genotype may not be involved in the female adolescents’impulsivity traits related to childhood maltreat?ment.