中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
16期
109-110,117
,共3页
小肠%胃肠间质瘤%临床病理%免疫组化
小腸%胃腸間質瘤%臨床病理%免疫組化
소장%위장간질류%림상병리%면역조화
Small intestine%Gastrointestinal stromal tumor%Clinicopathology%Immunohistochemistry
目的:探讨小肠原发胃肠间质瘤的临床病理学特征、免疫组化特点及鉴别诊断要点。方法对13例小肠原发胃肠间质瘤的病理形态和免疫组化特点观察,并进行文献复习和讨论。结果13例病例中男8例,女5例,年龄34~76岁,平均52岁。8例位于空肠,3例位于回肠,2例位于十二指肠。低危险度1例,中危险度4例,高危险度8例。肿瘤直径1.6~18 cm。13例中,梭形细胞型6例,上皮细胞型3例,混合细胞型4例。免疫组化13例CD117、DOG-1、Vimentin均阳性,13例Desmin、S-100均阴性。仅5例CD34阳性,5例SMA阳性,10例Nestin阳性,Ki-67阳性(+8%~+30%)。结论小肠间质瘤是较少见的消化道肿瘤,预后显著差于胃GIST。手术是有效的治疗方法。
目的:探討小腸原髮胃腸間質瘤的臨床病理學特徵、免疫組化特點及鑒彆診斷要點。方法對13例小腸原髮胃腸間質瘤的病理形態和免疫組化特點觀察,併進行文獻複習和討論。結果13例病例中男8例,女5例,年齡34~76歲,平均52歲。8例位于空腸,3例位于迴腸,2例位于十二指腸。低危險度1例,中危險度4例,高危險度8例。腫瘤直徑1.6~18 cm。13例中,梭形細胞型6例,上皮細胞型3例,混閤細胞型4例。免疫組化13例CD117、DOG-1、Vimentin均暘性,13例Desmin、S-100均陰性。僅5例CD34暘性,5例SMA暘性,10例Nestin暘性,Ki-67暘性(+8%~+30%)。結論小腸間質瘤是較少見的消化道腫瘤,預後顯著差于胃GIST。手術是有效的治療方法。
목적:탐토소장원발위장간질류적림상병이학특정、면역조화특점급감별진단요점。방법대13례소장원발위장간질류적병리형태화면역조화특점관찰,병진행문헌복습화토론。결과13례병례중남8례,녀5례,년령34~76세,평균52세。8례위우공장,3례위우회장,2례위우십이지장。저위험도1례,중위험도4례,고위험도8례。종류직경1.6~18 cm。13례중,사형세포형6례,상피세포형3례,혼합세포형4례。면역조화13례CD117、DOG-1、Vimentin균양성,13례Desmin、S-100균음성。부5례CD34양성,5례SMA양성,10례Nestin양성,Ki-67양성(+8%~+30%)。결론소장간질류시교소견적소화도종류,예후현저차우위GIST。수술시유효적치료방법。
Objective To investigate the clinical and pathological features,immune phenotype,diagnosis,differential diagnosis of small intestine gastrointestinal stromaI tumors (GIST). Methods Clinical manifestations,pathological fea-tures and immunohistochemical characteristics were analyzed in 13 cases of small intestine gastrointestinal stromal tu-mors with review of the relative literature. Results Of 13 cases,age ranged from 34 to 76 years(mean 52 years),includ-ing 8 males and 5 females. There were 8 cases in jejunum,3 cases in ileum,2 cases in duodenum. In 13 patients,1 case was low risk,4 cases were middle risk,and 8 cases were high risk The diameter of tumors was 1.6-18 cm. Of 13 cases,there were 6 cases of spindle cell type,3 cases of epithelioid cell type and 4 cases of mixed cell type.Immunohis-tochemically,tumor cells were positive for CD117,DOG-1,Vimentin,but negative for Desmin, S-100. CD34 and SMA were positive in 5 cases,nestin was positive in 10 cases. The positive rate of Ki-67 was from+8%to+30%. Conclusion Small intestinal stromal tumors are rare tumors of alimentary tract, the prognosis was significantly worse in gastric GIST. Surgery is the principal and effective procedure for the tumors.