CAJ | 학술논문

目的：观察传统免疫抑制剂(硫酸羟氯喹)联合他克莫司治疗口腔扁平苔藓的短期疗效和安全性。方法80例口腔扁平苔藓患者分为两组,实验组给予0.0015%他克莫司溶液每日2次含服及口服硫酸羟氯喹片100 mg,每日1次,对照组予口服硫酸羟氯喹片100 mg,每日1次,治疗观察4周,治疗结束时评价有效率和不良反应发生率。结果实验组治疗有效率为95.0%,对照组治疗有效率为35.0%,硫酸羟氯喹联合他克莫司对口腔扁平苔藓的短期疗效明显优于硫酸羟氯喹(字2=31.65,P=0.00),但两组不良反应率无明显差异。结论硫酸羟氯喹联合他克莫司对口腔扁平苔藓的短期疗效明显优于硫酸羟氯喹,安全有效,值得临床推广应用。
목적：관찰전통면역억제제(류산간록규)연합타극막사치료구강편평태선적단기료효화안전성。방법80례구강편평태선환자분위량조,실험조급여0.0015%타극막사용액매일2차함복급구복류산간록규편100 mg,매일1차,대조조여구복류산간록규편100 mg,매일1차,치료관찰4주,치료결속시평개유효솔화불량반응발생솔。결과실험조치료유효솔위95.0%,대조조치료유효솔위35.0%,류산간록규연합타극막사대구강편평태선적단기료효명현우우류산간록규(자2=31.65,P=0.00),단량조불량반응솔무명현차이。결론류산간록규연합타극막사대구강편평태선적단기료효명현우우류산간록규,안전유효,치득림상추엄응용。
Objective To observe the short-term curative effects and safety of conventional immunosuppressor (hydrox-ychloroquine sulphate) combined with tacrolimus in the treatment of oral lichen planus. Methods Eighty patients with oral lichen planus were assigned to two groups. The experiment group was sublingually given 0.0015%of tacrolimus so-lution twice a day, and was orally given 100 mg of hydroxychloroquine sulphate tablets once a day. The control group was orally given 100 mg of hydroxychloroquine sulphate tablets once a day. The treatment was observed for 4 weeks, and the effective rate and incidence of adverse effects at the end of the treatment were evaluated. Results The effective rate of experiment group was 95.0%, and the control group was 35.0%. The short-term curative effect of hydroxychloro-quine sulphate combined with tacrolimus in the treatment of oral lichen planus was significantly better than that of hydroxychloroquine sulphate alone (χ2=31.65, P=0.00), but the incidence of adverse had not significantly different be-tween two groups. Conclusion The short-term curative effect of hydroxychloroquine sulphate combined with tacrolimus in the treatment of oral lichen planus is significantly better than that of hydroxychloroquine sulphate alone, which is safe and effective, and is worthy of clinical promotion and application.