CAJ | 학술논문

目的探讨贲门失弛缓症(AC)患者的临床症状与高分辨率食管测压(HRM)参数的相关性.方法回顾性分析30例AC患者的临床资料,应用Eckardt评分评估症状严重程度,应用HRM参数评估食管动力情况并根据芝加哥分型将患者分为3种类型.采用Mann-Whitney U检验对非正态分布的定量资料进行比较,采用Spearman相关系数分析症状评分与测压参数的相关性.结果 Ⅱ型患者反流症状评分重于Ⅰ型[2.50(1.00)比1.00(1.50),U=56.000,P＜0.05];完整松弛压与AC患者总体的Eckardt总分、反流频率、体质量下降程度均具有中度相关性(r=0.528、0.441、0.662,P均＜0.05),与Ⅰ型患者的体质量下降程度具有强相关性(r=0.703,P＜0.05);食管下括约肌静息压与AC患者总体的体质量下降程度具有弱相关性(r=0.398,P＜0.05).结论不同类型AC患者的症状严重程度可能不同,HRM参数尤其是IRP对AC症状严重程度可能具有评估价值.
목적 탐토분문실이완증(AC)환자적림상증상여고분변솔식관측압(HRM)삼수적상관성.방법 회고성분석30례AC환자적림상자료,응용Eckardt평분평고증상엄중정도,응용HRM삼수평고식관동력정황병근거지가가분형장환자분위3충류형.채용Mann-Whitney U검험대비정태분포적정량자료진행비교,채용Spearman상관계수분석증상평분여측압삼수적상관성.결과 Ⅱ형환자반류증상평분중우Ⅰ형[2.50(1.00)비1.00(1.50),U=56.000,P＜0.05];완정송이압여AC환자총체적Eckardt총분、반류빈솔、체질량하강정도균구유중도상관성(r=0.528、0.441、0.662,P균＜0.05),여Ⅰ형환자적체질량하강정도구유강상관성(r=0.703,P＜0.05);식관하괄약기정식압여AC환자총체적체질량하강정도구유약상관성(r=0.398,P＜0.05).결론 불동류형AC환자적증상엄중정도가능불동,HRM삼수우기시IRP대AC증상엄중정도가능구유평고개치.
Objective To investigate the correlation between the clinical symptoms of patients with achalasia of cardia (AC) and high-resolution manometry (HRM) parameters.Methods The clinical data of 30 AC patients were retrospectively analyzed.The severe degree of symptoms was evaluated by Eckardt score questionnaires,and motility of esophagus was assessed by HRM parameters.According to Chicago classification,patients were divided into three types.Mann-Whitney U test was performed for non normal distribution quantitative data comparison.Spearman correlation was used to analyze the correlation between AC symptoms and the HRM parameters.Results The reflux symptom of type Ⅱ patients was more severe than that of type Ⅰ patients (2.50(1.00) vs 1.00(1.50),U=56.000,P＜0.05).The integrated relaxation pressure (IRP) was moderately correlated with total Eckardt score of all AC patients,the frequency of reflux and the degree of body weight loss (r=0.528,0.441 and 0.662,all P＜0.05),furthermore IRP was strongly correlated with the degree in weight loss in type Ⅰ AC patients (r =0.703,P＜ 0.05).Lower esophageal sphincter resting pressure was weakly correlated with the degree of weight loss in all AC patients (r=0.398,P＜0.05).Conclusions The degree of severity of symptoms may be different in different types of AC patients.HRM parameters,especially IRP,might play a role in the assessment of severity of AC symptoms.