CAJ | 학술논문

目的：探讨三维适形放射治疗用于鼻咽癌患者的临床疗效及安全性。方法选取2007年1月~2013年10月间我院收治的50例鼻咽癌患者，采用数字法随机分为治疗组和对照组各25例，对照组采用常规放疗+FP方案化疗，观察组则在常规放疗后进行三维适形放射治疗，并给予FP方案化疗，对比两组患者的临床疗效及腮腺毒性反应情况。结果近期疗效对比显示，治疗组患者总有效率为88.0%(22/25)，显著高于对照组的68.0%(17/25)，差异有统计学意义(P<0.05)；从两组患者的腮腺毒性反应情况来看，治疗组患者的芋级毒性发生率为8.0%(2/25)，与对照组的12.0%(3/25)对比并无显著差异(P跃0.05)。结论三维适形放射治疗用于鼻咽癌患者的近期疗效较好，毒性反应与单纯采用常规放疗并无明显差异，安全性较好，值得在临床上推广和应用。
목적：탐토삼유괄형방사치료용우비인암환자적림상료효급안전성。방법선취2007년1월~2013년10월간아원수치적50례비인암환자，채용수자법수궤분위치료조화대조조각25례，대조조채용상규방료+FP방안화료，관찰조칙재상규방료후진행삼유괄형방사치료，병급여FP방안화료，대비량조환자적림상료효급시선독성반응정황。결과근기료효대비현시，치료조환자총유효솔위88.0%(22/25)，현저고우대조조적68.0%(17/25)，차이유통계학의의(P<0.05)；종량조환자적시선독성반응정황래간，치료조환자적우급독성발생솔위8.0%(2/25)，여대조조적12.0%(3/25)대비병무현저차이(P약0.05)。결론삼유괄형방사치료용우비인암환자적근기료효교호，독성반응여단순채용상규방료병무명현차이，안전성교호，치득재림상상추엄화응용。
Objective To investigate the effects of three dimensional conformal radiation therapy for clinical efficacy and safety in patients with nasopharyngeal carcinoma . Methods Selected 50 cases of nasopharyngeal carcinoma patients from January 2007 to October 2013 in our hospital, they were randomly divided into the treatment group and the control group by digital method with 25 cases in each group,the control group used conventional radiotherapy and+FP chemotherapy,the observation group was carried out in three dimensional conformal radiotherapy with convention-al radiotherapy, and chemotherapy of FP regimen,the clinical curative effect and the parotid gland toxicity were com-pared between the two groups. Results The near future curative effect comparison,the total effective rate in treatment group was 88.0%(22/25),was significantly higher than that in control group 68.0%(17/25),the difference was statisti-cally significant(P<0.05);from the parotid gland toxicity reaction of two groups,the incidence rate of gradeⅢtoxicity in the treatment group was 8.0%(2/25),and 12.0%(3/25)in the control group without significant difference(P>0.05). Conclusion Three dimensional conformal radiation therapy for nasopharyngeal carcinoma patients with short-term effi-cacy, there is no difference of toxicity between the conventional radiotherapy and three climensional conformal radia-tion therapy,security is good,worthy of clinical popularization and application.