中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
16期
15-17
,共3页
刘玉玉%焦玉燕%李斑斑%滕清良
劉玉玉%焦玉燕%李斑斑%滕清良
류옥옥%초옥연%리반반%등청량
急性早幼粒细胞白血病%早期死亡%免疫表型%融合基因%基因突变
急性早幼粒細胞白血病%早期死亡%免疫錶型%融閤基因%基因突變
급성조유립세포백혈병%조기사망%면역표형%융합기인%기인돌변
Acute promyelocytic leukemia%Early death%Immunophenotype%Fusiongene%Gene mutations
目的:探讨急性早幼粒细胞白血病患者早期死亡危险因素。方法分析我院42例APL患者发病时的白细胞计数、血小板计数、纤维蛋白原含量等特点,并比较APL患者的免疫分型、融合基因及基因突变等因素。结果42例APL患者中,6例出现早期死亡,早期死亡率14.3%。其中4例死于脑出血,1例死于弥漫性血管内凝血并多脏器功能衰竭,1例死于心肌梗死。死亡组患者白细胞计数显著高于完全缓解组,血小板及纤维蛋白原计数均较完全缓解组患者低,5例为CD2+,5例为CD34和(或)HLA-DR+,4例存在FT3-ITD基因突变,与完全缓解组比较差异有统计学意义(P<0.05)。结论高白细胞血症、低血小板计数、低纤维蛋白原、CD2+、CD34和(或)HLA-DR+、FT3-ITD基因突变的急性早幼粒细胞白血病患者早期死亡率高。
目的:探討急性早幼粒細胞白血病患者早期死亡危險因素。方法分析我院42例APL患者髮病時的白細胞計數、血小闆計數、纖維蛋白原含量等特點,併比較APL患者的免疫分型、融閤基因及基因突變等因素。結果42例APL患者中,6例齣現早期死亡,早期死亡率14.3%。其中4例死于腦齣血,1例死于瀰漫性血管內凝血併多髒器功能衰竭,1例死于心肌梗死。死亡組患者白細胞計數顯著高于完全緩解組,血小闆及纖維蛋白原計數均較完全緩解組患者低,5例為CD2+,5例為CD34和(或)HLA-DR+,4例存在FT3-ITD基因突變,與完全緩解組比較差異有統計學意義(P<0.05)。結論高白細胞血癥、低血小闆計數、低纖維蛋白原、CD2+、CD34和(或)HLA-DR+、FT3-ITD基因突變的急性早幼粒細胞白血病患者早期死亡率高。
목적:탐토급성조유립세포백혈병환자조기사망위험인소。방법분석아원42례APL환자발병시적백세포계수、혈소판계수、섬유단백원함량등특점,병비교APL환자적면역분형、융합기인급기인돌변등인소。결과42례APL환자중,6례출현조기사망,조기사망솔14.3%。기중4례사우뇌출혈,1례사우미만성혈관내응혈병다장기공능쇠갈,1례사우심기경사。사망조환자백세포계수현저고우완전완해조,혈소판급섬유단백원계수균교완전완해조환자저,5례위CD2+,5례위CD34화(혹)HLA-DR+,4례존재FT3-ITD기인돌변,여완전완해조비교차이유통계학의의(P<0.05)。결론고백세포혈증、저혈소판계수、저섬유단백원、CD2+、CD34화(혹)HLA-DR+、FT3-ITD기인돌변적급성조유립세포백혈병환자조기사망솔고。
Objective To investigate risk factors for early death in acute promyelocytic leukemia patients. Methods The clinical characteristics including leucocyte counts at onset,platelet count and fibrinogen content of 42 patients with APL were evaluated. The factors of immunophenotype, genes fusion as well as gene mutations were compared. Results Among the 42 patients with APL,6 cases were observed early death with the early mortality rate of 14.3%. To be spe-cific,4 deaths were attributable to cerebral hemorrhage,whereas the other two were linked with disseminated intravas-cular coagulation complicated with multiple organ failure and myocardial infarction respectively. The leukocyte counts of dead patients were significantly more than complete remission group. At the same time, the blood platelet counts and the fibrinogen counts were all less than those of complete remission patients. 5 patients were confirmed as CD2+,5 cases were CD34 and/or HLA-DR+,and FLT3-ITD gene mutation was found in 4 subjects. Difference between the two groups was statistically significant(P<0.05). Conclusion Acute promyelocytic leukemia patients with leukocytosis,low platelet count, hypofibrinogenemia, CD2+, CD34 and/or HLA-DR+as well as FLT3-ITD gene mutation are at an increased risk of early death in the risk factor analysis.