承德医学院学报
承德醫學院學報
승덕의학원학보
JOURNAL OF CHENGDE MEDICAL
2015年
3期
186-188
,共3页
环黄芪醇%缺血再灌注%大鼠%局灶性脑梗死
環黃芪醇%缺血再灌註%大鼠%跼竈性腦梗死
배황기순%결혈재관주%대서%국조성뇌경사
Cycloastragenol%Ischemia and reperfusion%Rat%Focal cerebral infarction
目的：：探讨环黄芪醇对大鼠局灶性脑缺血再灌注损伤脑组织的保护作用。方法：采用线栓法建立大鼠局灶性脑缺血再灌注(缺血2h再灌注24h)模型并给予环黄芪醇干预，评价大鼠的Garcia JH神经功能评分，并采用TTC染色法计算大鼠的脑梗死灶容积百分比。结果：环黄芪醇中、高剂量组大鼠神经功能评分明显高于模型组(P＜0.05)，脑梗死灶容积百分比明显低于模型组(P＜0.05)。结论：环黄芪醇能提高脑缺血再灌注损伤大鼠的神经功能评分、缩小脑梗死体积，对局灶性脑缺血再灌注脑组织损伤具有保护作用。
目的：：探討環黃芪醇對大鼠跼竈性腦缺血再灌註損傷腦組織的保護作用。方法：採用線栓法建立大鼠跼竈性腦缺血再灌註(缺血2h再灌註24h)模型併給予環黃芪醇榦預，評價大鼠的Garcia JH神經功能評分，併採用TTC染色法計算大鼠的腦梗死竈容積百分比。結果：環黃芪醇中、高劑量組大鼠神經功能評分明顯高于模型組(P＜0.05)，腦梗死竈容積百分比明顯低于模型組(P＜0.05)。結論：環黃芪醇能提高腦缺血再灌註損傷大鼠的神經功能評分、縮小腦梗死體積，對跼竈性腦缺血再灌註腦組織損傷具有保護作用。
목적：：탐토배황기순대대서국조성뇌결혈재관주손상뇌조직적보호작용。방법：채용선전법건립대서국조성뇌결혈재관주(결혈2h재관주24h)모형병급여배황기순간예，평개대서적Garcia JH신경공능평분，병채용TTC염색법계산대서적뇌경사조용적백분비。결과：배황기순중、고제량조대서신경공능평분명현고우모형조(P＜0.05)，뇌경사조용적백분비명현저우모형조(P＜0.05)。결론：배황기순능제고뇌결혈재관주손상대서적신경공능평분、축소뇌경사체적，대국조성뇌결혈재관주뇌조직손상구유보호작용。
Objective:To investigate the protective effects of cycloastragenol on brain injury induced by focal cerebral ischemia reperfusion in rats.Methods:Focal cerebral ischemia reperfusion (ischemia 2h, reperfusion 24h) injury rats’ model was set up by blocking the middle cerebral artery with suture; before operation the rats were given cycloastragenol for 7 days. The Garcia JH neurological score of rats were evaluated; TTC method was used to calculate the infarction volume of rats.Results:The Garcia JH neurological score of rats in cycloastragenol high dose and middle dose group were obviously higher than that of rats in model group(P<0.05), but the infarction volume was obviously lower (P<0.05). Conclusions:Cycloastragenol can increase the neurological score and reduce infarction volume of cerebral ischemia reperfusion model rats, so it has protective effects on focal cerebral ischemia reperfusion brain injury.
