CAJ | 학술논문

二尖瓣装置在解剖结构或功能上的异常造成左心室收缩时左心室内血液部分反流到左心房即称为二尖瓣关闭不全（MR）。二尖瓣装置由二尖瓣环、瓣叶、腱索及其所连接的乳头肌等所组成。MR 动物模型的创建对于我们进一步研究 MR 的发病机制、进行性损害机制及治疗效果有着重要的意义。本文综述了目前国内外 MR 动物模型的建立及其手术治疗方法。
이첨판장치재해부결구혹공능상적이상조성좌심실수축시좌심실내혈액부분반류도좌심방즉칭위이첨판관폐불전（MR）。이첨판장치유이첨판배、판협、건색급기소련접적유두기등소조성。MR 동물모형적창건대우아문진일보연구 MR 적발병궤제、진행성손해궤제급치료효과유착중요적의의。본문종술료목전국내외 MR 동물모형적건립급기수술치료방법。
As the abnormal anatomical structure or dysfunction of the mitral valve apparatus,which is mitral regurgitation (MR),leading to the blood retrograde flow from the left ventricle into the left atrium in cardiac systole. The mitral valve appara-tus consists of the annulus,leaflets and tendinous chords,as well as papillary muscles connecting the chords. It is vital meaning that creating MR animal model can provide a further study for us to learn about the pathogenesis,the progressive damage mecha-nism and the effect of the treatment of MR. We reviewed the existing literature and have summarized various animal models of MR with specially focus on methods and operation.