CAJ | 학술논문

目的：对博思清与氯氮平治疗单纯型精神分裂症疗效与安全性进行评价．方法：研究对象选取本院2008-11／2014-12收治的100例符合 ICD-10单纯型精神分裂症诊断标准的患者，按随机方法分为两组．博思清组患者采用博思清治疗，氯氮平组患者给予氯氮平治疗．治疗3个月和6个月分别采用 PANSS 量表减分率评价疗效，对比分析两组患者治疗效果和不良反应的差异性．结果：经过3个月治疗后氯氮平组患者总有效率与博思清组相当（P ＞0．05）；而治疗6个月后博思清组治疗总有效率明显优于氯氮平组（P ＜0．05）；两组患者治疗期间不良反应发生率有显著差异，博思清组发生率明显低于氯氮平组（P ＜0．05）．结论：博思清和氯氮平治疗精神分裂症的近期效果相当，但从安全性和远期疗效来看，博思清有明显优势，安全性较高，值得推广．
목적：대박사청여록담평치료단순형정신분렬증료효여안전성진행평개．방법：연구대상선취본원2008-11／2014-12수치적100례부합 ICD-10단순형정신분렬증진단표준적환자，안수궤방법분위량조．박사청조환자채용박사청치료，록담평조환자급여록담평치료．치료3개월화6개월분별채용 PANSS 량표감분솔평개료효，대비분석량조환자치료효과화불량반응적차이성．결과：경과3개월치료후록담평조환자총유효솔여박사청조상당（P ＞0．05）；이치료6개월후박사청조치료총유효솔명현우우록담평조（P ＜0．05）；량조환자치료기간불량반응발생솔유현저차이，박사청조발생솔명현저우록담평조（P ＜0．05）．결론：박사청화록담평치료정신분렬증적근기효과상당，단종안전성화원기료효래간，박사청유명현우세，안전성교고，치득추엄．
AIM:To evaluate the efficacy and safety of aripi-prazole and clozapine in the treatment of simple type schizophreni-a.METHODS:100 cases of simple type schizophrenia meeting ICD-10 criteria were analyzed in our hospital from November 2008 to December 2014,and they were divided randomly into two groups.Aripiprazole group was treated with aripiprazol,while clozapine group was treated with clozapine.PANSS reducing rates were used to evaluate the curative effect after 3 months and half a year,and the difference treatment effect and adverse reaction of two groups were analyzed.RESULTS:The total effective rate of two groups was comparative after 3 months (P >0.05);and the total effective rate of aripiprazole group was better than clozapine group after half a year (P <0.05).The incidence of adverse reac-tion of two groups had significant difference,and the incidence of adverse reaction of aripiprazole is lower than clozapine group's (P <0.05).CONCLUSION:The effect is relatively in recent of aripiprazole and clozapine in the treatment of simple type schiz-ophrenia,but aripiprazole has obvious advantages for the long-term efficacy and safety.Its security is greater,and is worthy of promotion.