CAJ | 학술논문

目的：观察不同剂量重组人类促红细胞生成素（rh-EPO）对早产儿贫血的预防。方法：将88例早产儿随机分为两组，即小剂量组[300 U ／（kg·w）]42例、大剂量组[750 U ／（kg·w）]46例。出生后1周开始皮下注射 rh-EPO，隔日1次，3次／周，共6周。两组患儿均于出生后肌肉注射维生素K11 mg／次。结果：疗程结束后小剂量组血红蛋白、网织红细胞、红细胞压积比大剂量组下降程度明显，输血率差异显著。结论：rh-EPO 能预防早产儿贫血，大剂量[750 U ／（kg·w）]效果显著，且安全有效。
목적：관찰불동제량중조인류촉홍세포생성소（rh-EPO）대조산인빈혈적예방。방법：장88례조산인수궤분위량조，즉소제량조[300 U ／（kg·w）]42례、대제량조[750 U ／（kg·w）]46례。출생후1주개시피하주사 rh-EPO，격일1차，3차／주，공6주。량조환인균우출생후기육주사유생소K11 mg／차。결과：료정결속후소제량조혈홍단백、망직홍세포、홍세포압적비대제량조하강정도명현，수혈솔차이현저。결론：rh-EPO 능예방조산인빈혈，대제량[750 U ／（kg·w）]효과현저，차안전유효。
AIM:To research the preventional effect of recombi-nant human erythropoietin (rh-EPO)with different doses on ane-mia in premature infants.METHODS:The premature infants were divided randomly into two groups,42 cases in low dose group [300 U /(kg·w)],46 cases in high dose group [750 U /(kg · w)].rh-EPO was injected subcutaneously 1 week after birth,once another day,3 times per week,6 weeks in all.All the infants in two groups were given vitamin K1 1 mg/time with muscle injection,oral vitamin C 100 mg/d.RESULTS:After the course of treatment,hemoglobin,reticulocyte and HCT de-creased dramatically,the difference of blood transfusion between two groups was statistically significant.CONCLUSION:rh-EPO can prevent the anemia in premature infants and the high dose [750 U /(kg·w)]is effective and safe.