中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2015年
6期
480-485
,共6页
王亚%丛树艳%黄奔鑫%赵秀兰%邵华
王亞%叢樹豔%黃奔鑫%趙秀蘭%邵華
왕아%총수염%황분흠%조수란%소화
脑梗死%动脉粥样硬化%基质金属蛋白酶10
腦梗死%動脈粥樣硬化%基質金屬蛋白酶10
뇌경사%동맥죽양경화%기질금속단백매10
Brain infarction%Atherosclerosis%Matrix metalloproteinase 10
目的 基质金属蛋白酶-10(MMP-10)与动脉粥样硬化有着密切关系,且近期研究发现,MMP-10的血清水平在急性脑梗死鼠模型的梗死组织中有所升高,但是对于急性脑梗死患者的MMP-10血清水平至今尚无相关研究.我们研究了急性脑梗死患者MMP-10水平的变化及其与急性缺血性脑卒中试验病因分型、病情严重程度、危险因素和颈动脉斑块之间的关系.方法 选择2012年4-12月在我院神经内科住院的109例急性脑梗死患者作为病例组,另选85名健康体检者作为对照组.取病例组和对照组外周血,测定MMP-10血清水平,并搜集入组患者资料进行分组及统计学分析.结果 急性脑梗死病例组MMP-10血清水平明显高于对照组[分别为6.59 (6.07,7.31) μg/L、5.16 (3.87,5.94) μg/L,Z=8.33,P＜0.01];NIHSS评分与MMP-10之间呈正相关(r=0.204,P=0.037);根据危险因素分组,血脂异常组较血脂正常组MMP-10血清水平升高(Z =2.07,P=0.042);MMP-10与低密度脂蛋白(LDL)-胆固醇水平呈正相关(r=0.248,P=0.040),而与凝血酶激活的纤溶抑制物(TAFI)呈负相关(r=-0.208,P=0.030);病例组中,不稳定性斑块组MMP-10血清水平较稳定性斑块组升高,且两组间的差异具有统计学意义[分别为6.62 (6.13,7.36) μg/L、6.10(6.00,6.46) μg/L,Z=2.12,P=0.034].结论 急性脑梗死患者体内MMP-10血清水平较健康人群显著升高,且病情越严重,MMP-10血清水平升高越明显.血脂异常组的MMP-10血清水平高于血脂正常组,且MMP-10血清水平与LDL-胆固醇水平呈正相关,与TAFI水平呈负相关,提示MMP-10可能与动脉粥样硬化的发生发展密切相关.MMP-10血清水平可能与不稳定性斑块的形成及破裂有关,在急性血栓形成的机制中意义深远.
目的 基質金屬蛋白酶-10(MMP-10)與動脈粥樣硬化有著密切關繫,且近期研究髮現,MMP-10的血清水平在急性腦梗死鼠模型的梗死組織中有所升高,但是對于急性腦梗死患者的MMP-10血清水平至今尚無相關研究.我們研究瞭急性腦梗死患者MMP-10水平的變化及其與急性缺血性腦卒中試驗病因分型、病情嚴重程度、危險因素和頸動脈斑塊之間的關繫.方法 選擇2012年4-12月在我院神經內科住院的109例急性腦梗死患者作為病例組,另選85名健康體檢者作為對照組.取病例組和對照組外週血,測定MMP-10血清水平,併搜集入組患者資料進行分組及統計學分析.結果 急性腦梗死病例組MMP-10血清水平明顯高于對照組[分彆為6.59 (6.07,7.31) μg/L、5.16 (3.87,5.94) μg/L,Z=8.33,P＜0.01];NIHSS評分與MMP-10之間呈正相關(r=0.204,P=0.037);根據危險因素分組,血脂異常組較血脂正常組MMP-10血清水平升高(Z =2.07,P=0.042);MMP-10與低密度脂蛋白(LDL)-膽固醇水平呈正相關(r=0.248,P=0.040),而與凝血酶激活的纖溶抑製物(TAFI)呈負相關(r=-0.208,P=0.030);病例組中,不穩定性斑塊組MMP-10血清水平較穩定性斑塊組升高,且兩組間的差異具有統計學意義[分彆為6.62 (6.13,7.36) μg/L、6.10(6.00,6.46) μg/L,Z=2.12,P=0.034].結論 急性腦梗死患者體內MMP-10血清水平較健康人群顯著升高,且病情越嚴重,MMP-10血清水平升高越明顯.血脂異常組的MMP-10血清水平高于血脂正常組,且MMP-10血清水平與LDL-膽固醇水平呈正相關,與TAFI水平呈負相關,提示MMP-10可能與動脈粥樣硬化的髮生髮展密切相關.MMP-10血清水平可能與不穩定性斑塊的形成及破裂有關,在急性血栓形成的機製中意義深遠.
목적 기질금속단백매-10(MMP-10)여동맥죽양경화유착밀절관계,차근기연구발현,MMP-10적혈청수평재급성뇌경사서모형적경사조직중유소승고,단시대우급성뇌경사환자적MMP-10혈청수평지금상무상관연구.아문연구료급성뇌경사환자MMP-10수평적변화급기여급성결혈성뇌졸중시험병인분형、병정엄중정도、위험인소화경동맥반괴지간적관계.방법 선택2012년4-12월재아원신경내과주원적109례급성뇌경사환자작위병례조,령선85명건강체검자작위대조조.취병례조화대조조외주혈,측정MMP-10혈청수평,병수집입조환자자료진행분조급통계학분석.결과 급성뇌경사병례조MMP-10혈청수평명현고우대조조[분별위6.59 (6.07,7.31) μg/L、5.16 (3.87,5.94) μg/L,Z=8.33,P＜0.01];NIHSS평분여MMP-10지간정정상관(r=0.204,P=0.037);근거위험인소분조,혈지이상조교혈지정상조MMP-10혈청수평승고(Z =2.07,P=0.042);MMP-10여저밀도지단백(LDL)-담고순수평정정상관(r=0.248,P=0.040),이여응혈매격활적섬용억제물(TAFI)정부상관(r=-0.208,P=0.030);병례조중,불은정성반괴조MMP-10혈청수평교은정성반괴조승고,차량조간적차이구유통계학의의[분별위6.62 (6.13,7.36) μg/L、6.10(6.00,6.46) μg/L,Z=2.12,P=0.034].결론 급성뇌경사환자체내MMP-10혈청수평교건강인군현저승고,차병정월엄중,MMP-10혈청수평승고월명현.혈지이상조적MMP-10혈청수평고우혈지정상조,차MMP-10혈청수평여LDL-담고순수평정정상관,여TAFI수평정부상관,제시MMP-10가능여동맥죽양경화적발생발전밀절상관.MMP-10혈청수평가능여불은정성반괴적형성급파렬유관,재급성혈전형성적궤제중의의심원.
Objective Matrix metalloproteinase-10 (MMP-10) has been shown to be highly associated with atherosclerosis.Recent studies showed that levels of MMP-10 were elevated in infarcted tissues in acute ischemic stoke.However,serum levels of MMP-10 in patients with acute ischemic stroke have never been studied previously.This study aims to investigate the serum levels of MMP-10 in patients with acute ischemic stroke,and evaluate the association of serum levels of MMP-10 with stroke subtypes based on Trial of Org 10 172 in acute stroke treatment classifications,the severity of stroke,risk factors and carotid artery plaque.Methods The circulating levels of MMP-10 were measured by enzyme linked immunosorbent assay in 194 subjects,including 109 patients who were diagnosed as acute ischemic stroke in the Department of Neurology,Shengjing Hospital,China Medical University from April to December 2012,and the 85 healthy controls.Results Patients with acute ischemic stroke had higher serum levels of MMP-10 compared with healthy controls (6.59 (6.07,7.31) μg/L vs 5.16 (3.87,5.94) μg/L,Z =8.33,P ＜ 0.01).NIHSS score had positive correlation with serum levels of MMP-10 (r =0.204,P =0.037).Classified by risk factors,we compared the MMP-10 levels of subsets,and results displayed that statistically significant difference existed between dyslipidemia subset and non-dyslipidemia subset (Z =2.07,P =0.042).MMP-10 levels had positive correlation with serum levels of LDL-cholesterol (r =0.248,P =0.040),but negative correlation with thrombin-activatable fibrinolysis inhibitor (TAFI;r =-0.208,P =0.030).The subset with unstable plaques had higher MMP-10 levels than that with stable plaque (6.62 (6.13,7.36) μg/L) vs 6.10 (6.00,6.46) μg/L,Z =2.12,P =0.034),implying the relationship of MMP-10 and atherosclerosis.Conclusions Patients with acute ischemic stroke have higher serum levels of MMP-10 compared with the healthy controls,and MMP-10 levels have positive correlation with the severity of stroke.MMP-10 is associated with the subtypes of stroke classified by risk factors,and dyslipidemia subset has higher levels of MMP-10 than that of non-dyslipidemia subset.MMP-10 has positive correlation with LDL-cholesterol,but negative correlation with TAFI.MMP-10 may be involved in the process of formation and disruption of unstable plaques,which contribute to the stenosis of arteries and onset of acute ischemic stroke.
