CAJ | 학술논문

目的：研究长期应用质子泵抑制剂是否可影响钙的吸收，从而加重或导致骨质疏松。方法选取在我科治疗的50例长期（大于3个月）口服质子泵抑制剂患者为调查对象，分别于服药前、服药1年后、服药2年后测定其骨密度及骨源性碱性磷酸酶活性。结果所调查患者服药2年后骨密度明显低于服药前及服药1年后（ P＜0．05），骨源性碱性磷酸酶活性明显高于服药前及服药1年后（P＜0．05），差异有统计学意义。服药1年后与服药前骨密度及骨源性碱性磷酸酶活性测定比较，差异无统计学意义（ P＞0．05）。结论长时间服用质子泵抑制剂可加重或导致骨质疏松。
목적：연구장기응용질자빙억제제시부가영향개적흡수，종이가중혹도치골질소송。방법선취재아과치료적50례장기（대우3개월）구복질자빙억제제환자위조사대상，분별우복약전、복약1년후、복약2년후측정기골밀도급골원성감성린산매활성。결과소조사환자복약2년후골밀도명현저우복약전급복약1년후（ P＜0．05），골원성감성린산매활성명현고우복약전급복약1년후（P＜0．05），차이유통계학의의。복약1년후여복약전골밀도급골원성감성린산매활성측정비교，차이무통계학의의（ P＞0．05）。결론장시간복용질자빙억제제가가중혹도치골질소송。
Objective To study whether long-term proton pump inhibitors can affect the absorption of calcium to cause or aggravate osteoporosis.Methods Selecting 50 patients who took proton pump inhibitors ( PPIs) for long-term ( more than 3 months) as the experi-mental group, and determining bone density and bone alkaline phosphatase before treatment, after 1 year and 2 years respectively.Results After 2 years,bone density was significantly lower than that before treatment and after 1 year (P<0.05).Bone alkaline phosphatase was significantly higher than that before treatment and after 1 year ( P<0.05 ) .The difference was statistically significant.The comparison of bone mineral density and bone alkaline phosphatase had no significant difference between before treatment and after 1 year ( P >0.05). Conclusion Long time taking PPI can ause or aggravate osteoporosis.