CAJ | 학술논문

目的：对常年性变应性鼻炎特异性免疫治疗的临床疗效进行研究，希望可以为临床治疗提供借鉴。方法对2011－01～2011－12间在我院用特异性免疫治疗方法治疗常年性变应性鼻炎的205例患者进行回顾分析，并将其作为观察组，经过三年治疗后，在2014年对这205例患者进行回访；然后选取同时期用传统抗组胺类药物联合激素治疗的205例常年性变应性鼻炎患者作为对照组，对比两组患者整体疗效的差异，在治疗前后对这两组的患者进行免疫学检查，观察其免疫学功能的改善情况。结果两组患者总有效率都超过85％，说明两组患者的治疗方法均有明显的疗效，但是差异不具有统计学意义（ P＞0．05）；免疫学功能检查显示，在治疗前后观察组有明显的改善，但是对照组这几种功能水平检测则没有明显改善，差异具有统计学意义（ P＜0．05）。结论特异性免疫治疗常年性变应性鼻炎具有良好的临床疗效，且对于免疫功能有明显的改善作用，能够有效预防和治疗常年性变应性鼻炎，因此值得在临床上大力推广。
목적：대상년성변응성비염특이성면역치료적림상료효진행연구，희망가이위림상치료제공차감。방법대2011－01～2011－12간재아원용특이성면역치료방법치료상년성변응성비염적205례환자진행회고분석，병장기작위관찰조，경과삼년치료후，재2014년대저205례환자진행회방；연후선취동시기용전통항조알류약물연합격소치료적205례상년성변응성비염환자작위대조조，대비량조환자정체료효적차이，재치료전후대저량조적환자진행면역학검사，관찰기면역학공능적개선정황。결과량조환자총유효솔도초과85％，설명량조환자적치료방법균유명현적료효，단시차이불구유통계학의의（ P＞0．05）；면역학공능검사현시，재치료전후관찰조유명현적개선，단시대조조저궤충공능수평검측칙몰유명현개선，차이구유통계학의의（ P＜0．05）。결론특이성면역치료상년성변응성비염구유량호적림상료효，차대우면역공능유명현적개선작용，능구유효예방화치료상년성변응성비염，인차치득재림상상대력추엄。
Objective To study the clinical efficacy of perennial allergic rhinitis specific immune therapy, hoping to provide reference for the clinical treatment of.Methods For 205 cases of 2011-01~2011-12 in our hospital with specific immune therapy for perennial allergic rhinitis patients were retrospectively analyzed, as the observation group, after three years of treatment, pay a return visit to the 205 patients in 2014;205 cases of perennial allergic rhinitis patients and then take the same period with traditional antihistamines drugs com-bined hormone therapy as the control group, the difference in the overall effect of the two groups, Immunology Examination of the two groups of patients before and after treatment, improvement of immunological function of observation period.Results The total efficiency of two groups of patients were more than 85%, shows obvious curative effect of therapy has two groups of patients, but the difference is not obvi-ous, is not statistically significant (P>0.05);second, immunological function tests showed.The observation group venous blood IL-2, IL4 and IL5 levels were significantly improved in the control group before and after treatment, but the detection of several functional level was greatly improved, with significant difference (P<0.05).Conclusion The specific immune therapy has a good clinical curative effect of perennial allergic rhinitis, and significant improvement for immune function, can be effective in the prevention and treatment of allergic rhinitis, so it is worth popularizing in clinic.