CAJ | 학술논문

目的：探讨异体淋巴细胞免疫治疗在原因不明的复发性流产中的应用意义。方法采用临床试验流行病学设计，纳入原因不明复发性流产患者96例，分为治疗组54例和对照组42例，治疗组进行异体淋巴细胞免疫治疗，怀孕后在常规保胎基础上进行一个疗程异体淋巴细胞免疫治疗。对照组在怀孕后仅作常规保胎治疗。比较两组治疗结局、封闭抗体、抗微淋巴细胞毒抗体、免疫球蛋白、淋巴细胞亚群水平，并检测治疗过程安全性。结果治疗组患者的妊娠成功率显著高于对照组患者的妊娠成功率，差异具有统计学意义（ P＜0．05）。治疗后治疗组封闭抗体、抗微淋巴细胞毒抗体检测（ APCA）、免疫球蛋白、淋巴细胞亚群的检测与治疗组治疗前，及对照组的检测结果相比，除了IgA水平外，均具有统计学差异（P＜0．05）。治疗过程中暂未发现及发生不良事件。结论异体淋巴细胞免疫治疗原因不明的复发性流产，能够显著提高妊娠成功率，安全性高，值得临床应用推广。
목적：탐토이체림파세포면역치료재원인불명적복발성유산중적응용의의。방법채용림상시험류행병학설계，납입원인불명복발성유산환자96례，분위치료조54례화대조조42례，치료조진행이체림파세포면역치료，부잉후재상규보태기출상진행일개료정이체림파세포면역치료。대조조재부잉후부작상규보태치료。비교량조치료결국、봉폐항체、항미림파세포독항체、면역구단백、림파세포아군수평，병검측치료과정안전성。결과치료조환자적임신성공솔현저고우대조조환자적임신성공솔，차이구유통계학의의（ P＜0．05）。치료후치료조봉폐항체、항미림파세포독항체검측（ APCA）、면역구단백、림파세포아군적검측여치료조치료전，급대조조적검측결과상비，제료IgA수평외，균구유통계학차이（P＜0．05）。치료과정중잠미발현급발생불량사건。결론이체림파세포면역치료원인불명적복발성유산，능구현저제고임신성공솔，안전성고，치득림상응용추엄。
Objective To evaluate the clinical effect and safety of allogeneic lymphocyte immunotherapy in treating unexplained recur-rent spontaneous abortion.Methods Adopting the clinical trial designs, 96 cases of unexplained recurrent spontaneous abortion patients were included into our study, 54 patients were divided into the treatment group and the other 42 cases were into the control group.The pa-tients in the treatment group were underwent allogeneic lymphocyte immunotherapy with routine tocolytic therapy, while the control group on-ly were underwent a routine tocolysis therapy.Evaluate the clinical effect by the level of some important immune markers and the pregnancy success rate and monitor the safety of this treatment.Results The pregnancy success rate of patients in the treatment group was significantly higher than that in the control group (P<0.05).After the treatment, except the level of the IgA level, the level of blocking antibody, AP-CA detection ( APCA) , immunoglobulin, lymphocyte subsets were statistically different from those in the control group and those before the treatment ( P<0.05).And adverse events were not found.Conclusion Allogeneic lymphocyte immunotherapy can significantly improve the success rate of pregnancy among the patients with unexplained recurrent spontaneous abortion, of high safety, which is worthy of clinical application.