CAJ | 학술논문

目的：观察和分析高胆红素血症对新生儿神经行为发育的影响及治疗。方法将我院于2012年9月～2014年9月诊治的120例高胆红素血症患儿依据血清中胆红素的水平分组，分成实验组和对照组。实验组：分为高胆红素血症Ⅰ（高于342.0μmol/L）、高胆红素血症Ⅱ（256.0～342.0μmol/L）、高胆红素血症Ⅲ（220.0～256.0μmol/L），行干预治疗，出生后一周、二周、四周分别对新生儿神经行为评分；对照组为正常新生儿，比较两组患者的临床效果。结果两组患儿神经行为的评分与体内胆红素的水平呈负相关，高胆红素血症Ⅰ神经行为的评分最低，高胆红素血症Ⅱ、高胆红素血症Ⅲ较为次之。对照组所得评分最高，高胆红素血症Ⅰ和高胆红素血症Ⅱ与对照组具有统计学差异， P<0.05。结论高胆红素血症影响新生儿神经行为发育，进行早期的干预治疗能有效改善症状。
목적：관찰화분석고담홍소혈증대신생인신경행위발육적영향급치료。방법장아원우2012년9월～2014년9월진치적120례고담홍소혈증환인의거혈청중담홍소적수평분조，분성실험조화대조조。실험조：분위고담홍소혈증Ⅰ（고우342.0μmol/L）、고담홍소혈증Ⅱ（256.0～342.0μmol/L）、고담홍소혈증Ⅲ（220.0～256.0μmol/L），행간예치료，출생후일주、이주、사주분별대신생인신경행위평분；대조조위정상신생인，비교량조환자적림상효과。결과량조환인신경행위적평분여체내담홍소적수평정부상관，고담홍소혈증Ⅰ신경행위적평분최저，고담홍소혈증Ⅱ、고담홍소혈증Ⅲ교위차지。대조조소득평분최고，고담홍소혈증Ⅰ화고담홍소혈증Ⅱ여대조조구유통계학차이， P<0.05。결론고담홍소혈증영향신생인신경행위발육，진행조기적간예치료능유효개선증상。
Objective To observe and analyze the impact and treatment of hyperbilirubinemia infant neurobehavioral development. Methods 120 cases of hyperbilirubinemia in children with hyperlipidemia in our hospital from September 2012 to September 2014 admitted on the basis of serum bilirubin level grouping,divided into experimental and control groups. Experimental group: divided hyperbilirubinemiaⅠ(higher than 342.0 μmol /L), hyperbilirubinemia Ⅱ(256.0 ~ 342.0 μmol/L),hyperbilirubinemia Ⅲ(220.0~256.0μmol/L),the line intervention,one week after birth, two weeks,four weeks,respectively,the newborn neurobehavioral scores,control group of normal infants,the clinical results of the two groups were compared. Results The results showed a level of bilirubin in the body score two groups of children with neurobehavioral negative correlation, hyperbilirubinemiaⅠneurobehavioral scores lowest,hyperbilirubinemiaⅡ,Ⅲhyperbilirubinemia more fol owed. The obtained the highest scores in the control group,hyperbilirubinemia and hyperbilirubinemiaⅠ,Ⅱand control group was statistical y significant difference(P<0.05). Conclusion Hyperbilirubinemia affect infant neurobehavioral development,early intervention therapy can improve symptoms.