肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2015年
5期
289-293
,共5页
陈波%李晔雄%王维虎%金晶%王淑莲%刘跃平%宋永文%房辉%任骅
陳波%李曄雄%王維虎%金晶%王淑蓮%劉躍平%宋永文%房輝%任驊
진파%리엽웅%왕유호%금정%왕숙련%류약평%송영문%방휘%임화
淋巴瘤,结外NK-T细胞%第二原发恶性肿瘤%发病率
淋巴瘤,結外NK-T細胞%第二原髮噁性腫瘤%髮病率
림파류,결외NK-T세포%제이원발악성종류%발병솔
Lymphoma,extranodal NK-T-cell%Second malignant neoplasm%Incidence rate
目的 分析早期结外鼻型NK/T细胞淋巴瘤(NKTCL)经治疗后生存超过3年患者第二原发恶性肿瘤(SMN)的发病风险.方法 1983年1月至2007年12月共174例ⅠE~ⅡE期NKTCL患者,经治疗后生存超过3年,其中50例接受单纯放疗,120例接受综合治疗,4例接受单纯化疗.采用中国2000年人口年龄构成比和国际通用的人口年龄构成比计算年龄调整标化发病率(中国)(ASRChina)和年龄调整标化发病率(世界)(ASR World).结果 中位随诊8.3年(3.1~35.6年),9例(5.2%)患者在随诊期间发生SMN,距离初诊NKTCL的中位时间间隔为12.6年(0.9~ 18.5年).7例为实体肿瘤,2例为恶性淋巴瘤.5、10、15年的累积发病率分别为1.2%、2.4%和13.7%.全组患者粗发病率为531.6/105人年,ASR China和ASR World分别为294.5/105人年和243.7/105人年,年龄调整累积发病率(0~74岁)为22.4%.所有发病率均高于2010年中国癌症发病率报告中普通人群恶性肿瘤的发病率.结论 早期NKTCL经治疗后获得长期生存患者的SMN发病率明显高于普通人群恶性肿瘤的发病率,NKTCL初诊后的10~ 15年是SMN的高发时段,长期生存NKTCL患者随诊时应注意SMN的可能性.
目的 分析早期結外鼻型NK/T細胞淋巴瘤(NKTCL)經治療後生存超過3年患者第二原髮噁性腫瘤(SMN)的髮病風險.方法 1983年1月至2007年12月共174例ⅠE~ⅡE期NKTCL患者,經治療後生存超過3年,其中50例接受單純放療,120例接受綜閤治療,4例接受單純化療.採用中國2000年人口年齡構成比和國際通用的人口年齡構成比計算年齡調整標化髮病率(中國)(ASRChina)和年齡調整標化髮病率(世界)(ASR World).結果 中位隨診8.3年(3.1~35.6年),9例(5.2%)患者在隨診期間髮生SMN,距離初診NKTCL的中位時間間隔為12.6年(0.9~ 18.5年).7例為實體腫瘤,2例為噁性淋巴瘤.5、10、15年的纍積髮病率分彆為1.2%、2.4%和13.7%.全組患者粗髮病率為531.6/105人年,ASR China和ASR World分彆為294.5/105人年和243.7/105人年,年齡調整纍積髮病率(0~74歲)為22.4%.所有髮病率均高于2010年中國癌癥髮病率報告中普通人群噁性腫瘤的髮病率.結論 早期NKTCL經治療後穫得長期生存患者的SMN髮病率明顯高于普通人群噁性腫瘤的髮病率,NKTCL初診後的10~ 15年是SMN的高髮時段,長期生存NKTCL患者隨診時應註意SMN的可能性.
목적 분석조기결외비형NK/T세포림파류(NKTCL)경치료후생존초과3년환자제이원발악성종류(SMN)적발병풍험.방법 1983년1월지2007년12월공174례ⅠE~ⅡE기NKTCL환자,경치료후생존초과3년,기중50례접수단순방료,120례접수종합치료,4례접수단순화료.채용중국2000년인구년령구성비화국제통용적인구년령구성비계산년령조정표화발병솔(중국)(ASRChina)화년령조정표화발병솔(세계)(ASR World).결과 중위수진8.3년(3.1~35.6년),9례(5.2%)환자재수진기간발생SMN,거리초진NKTCL적중위시간간격위12.6년(0.9~ 18.5년).7례위실체종류,2례위악성림파류.5、10、15년적루적발병솔분별위1.2%、2.4%화13.7%.전조환자조발병솔위531.6/105인년,ASR China화ASR World분별위294.5/105인년화243.7/105인년,년령조정루적발병솔(0~74세)위22.4%.소유발병솔균고우2010년중국암증발병솔보고중보통인군악성종류적발병솔.결론 조기NKTCL경치료후획득장기생존환자적SMN발병솔명현고우보통인군악성종류적발병솔,NKTCL초진후적10~ 15년시SMN적고발시단,장기생존NKTCL환자수진시응주의SMN적가능성.
Objective To estimate risk and incidence of second malignant neoplasms (SMN) among long-term survivors of early stage extranodal nasal-type natural killer/T-cell lymphoma (NKTCL).Methods Between January 1983 and December 2007,174 patients with stage Ⅰ E and Ⅱ E NKTCL survived 3 or more years after treatment.Of them,50 patients were treated with radiotherapy alone,120 patients with combined modality therapy,and 4 patients with chemotherapy alone.The China 2010 population census data and Segi' s world population data were used for calculating the age-standardized cancer incidence rates.Results Median follow-up time was 8.3 years (3.1-35.6 years) for all patients.Nine (5.2 %) SMN were recorded.The median time to SMN was 12.6 years (0.9-18.5 years) from diagnosis of NKTCL.Seven patients had solid tumors,and 2 had other type of malignant lymphomas.The cumulative incidence rates at 5-year,10-year and 15-year were 1.2 %,2.4 % and 13.7 %,respectively.The crude incidence was 531.6/105 person-years,the age-standardized rates by Chinese standard population (ASR China) and world standard population (ASR world) were 294.5/105 and 243.7/105,respectively,and the cumulative incidence rate (0-74 years old) was 22.4 %.All of them were higher than the cancer incidence rates for general population in China in 2010.Conclusions A frequency of SMN in patients with NKTCL is higher than that expected in the general population.The patients have more risk for SMN during 10 to 15 years after diagnosis of NKTCL.Patients with long-term survival are at higher risk of SMN and should be carefully followed-up.