肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2015年
5期
336-338
,共3页
王维军%杨华%刘沣%向欣%张伟豪
王維軍%楊華%劉灃%嚮訢%張偉豪
왕유군%양화%류풍%향흔%장위호
神经丛素A1%细胞增殖抗原%胶质瘤%预后
神經叢素A1%細胞增殖抗原%膠質瘤%預後
신경총소A1%세포증식항원%효질류%예후
plexinA1%Ki-67%Glioma%Prognosis
目的 探讨神经丛素A1(plexinA1)和细胞增殖抗原(Ki-67)在人脑胶质瘤中的表达及其临床意义.方法 收集脑胶质瘤手术患者胶质瘤标本43例,按病理分级将标本分为Ⅰ～Ⅱ级组(18例)、Ⅲ～Ⅳ级组(25例),采用免疫组织化学法检测标本中plexinA1和Ki-67的阳性表达,比较不同病理分级标本中的阳性表达及其意义,分析plexinA1和Ki-67的相关性.结果 PlexinA1在Ⅰ～Ⅱ级组和Ⅲ～Ⅳ级组的阳性表达率分别是22.22 ％(4/18)和72.00％(18/25),差异有统计学意义(P＜0.05).Ki-67在Ⅰ～Ⅱ级组和Ⅲ～Ⅳ级组的阳性表达率分别是16.67％(3/18)和56.00％(14/25),差异有统计学意义(P＜0.05).plexinA1和Ki-67在人脑胶质瘤组织中的表达呈正相关性(r=0.997,P＜0.05).结论 plexinA1在恶性程度较高的胶质瘤标本中的阳性表达率较高,有助于对患者预后的评估;plexinA1和Ki-67在人脑胶质瘤的发生、发展中可能起协同作用.
目的 探討神經叢素A1(plexinA1)和細胞增殖抗原(Ki-67)在人腦膠質瘤中的錶達及其臨床意義.方法 收集腦膠質瘤手術患者膠質瘤標本43例,按病理分級將標本分為Ⅰ～Ⅱ級組(18例)、Ⅲ～Ⅳ級組(25例),採用免疫組織化學法檢測標本中plexinA1和Ki-67的暘性錶達,比較不同病理分級標本中的暘性錶達及其意義,分析plexinA1和Ki-67的相關性.結果 PlexinA1在Ⅰ～Ⅱ級組和Ⅲ～Ⅳ級組的暘性錶達率分彆是22.22 ％(4/18)和72.00％(18/25),差異有統計學意義(P＜0.05).Ki-67在Ⅰ～Ⅱ級組和Ⅲ～Ⅳ級組的暘性錶達率分彆是16.67％(3/18)和56.00％(14/25),差異有統計學意義(P＜0.05).plexinA1和Ki-67在人腦膠質瘤組織中的錶達呈正相關性(r=0.997,P＜0.05).結論 plexinA1在噁性程度較高的膠質瘤標本中的暘性錶達率較高,有助于對患者預後的評估;plexinA1和Ki-67在人腦膠質瘤的髮生、髮展中可能起協同作用.
목적 탐토신경총소A1(plexinA1)화세포증식항원(Ki-67)재인뇌효질류중적표체급기림상의의.방법 수집뇌효질류수술환자효질류표본43례,안병리분급장표본분위Ⅰ～Ⅱ급조(18례)、Ⅲ～Ⅳ급조(25례),채용면역조직화학법검측표본중plexinA1화Ki-67적양성표체,비교불동병리분급표본중적양성표체급기의의,분석plexinA1화Ki-67적상관성.결과 PlexinA1재Ⅰ～Ⅱ급조화Ⅲ～Ⅳ급조적양성표체솔분별시22.22 ％(4/18)화72.00％(18/25),차이유통계학의의(P＜0.05).Ki-67재Ⅰ～Ⅱ급조화Ⅲ～Ⅳ급조적양성표체솔분별시16.67％(3/18)화56.00％(14/25),차이유통계학의의(P＜0.05).plexinA1화Ki-67재인뇌효질류조직중적표체정정상관성(r=0.997,P＜0.05).결론 plexinA1재악성정도교고적효질류표본중적양성표체솔교고,유조우대환자예후적평고;plexinA1화Ki-67재인뇌효질류적발생、발전중가능기협동작용.
Objective To explore expression of plexinA1 and Ki-67 in tissue of human brain glioma cells and their clinical significance.Methods 43 specimens from patients with brain glioma were collected.Immunohistochemical (IHC) staining was used for detecting the expression of tissue plexinA1 and Ki-67 in human glioma cells of 43 cases of patients with brain glioma.The positive expression rate of plexinA1 and Ki-67 among the different pathological grade tissues and their clinical significance were analyzed.So did correlation studies about plexinA1 and Ki-67.Results The positive expression rates of plexinA1 in Ⅰ-Ⅱ grade group (18 cases) and Ⅲ-Ⅳ grade group (25 cases) were 22.22 ％ (4/18) and 72.00 ％ (18/25) (P ＜ 0.05).The positive expression rates of Ki-67 in Ⅰ-Ⅱ grade group and Ⅲ-Ⅳ grade group were 16.67 ％ (3/18) and 56.00 ％ (14/25),respectively (P ＜ 0.05).PlxinA1 and Ki-67 expression in the tissue of human brain glioma were positively correlated (r =0.997,P ＜ 0.05).Conclusions The positive expression rate of plexinA1 is higher in high malignancy human glioma group than that in low malignancy group which has an important reference value in the estimation of prognosis for human glioma.PlexinA1 and Ki-67 maybe synergism in occurrence and development of glioma.
