CAJ | 학술논문

目的：研究血清同型半胱氨酸（Hcy）水平与急性脑梗死发病的关系及药物干预治疗后同型半胱氨酸水平变化及预后分析。方法收集100例急性脑梗死患者，治疗组50例、对照组50例，分别于治疗前及治疗后7天采取血液标本，采用酶联免疫法测定Hcy，比较治疗组与对照组血清Hcy水平变化，治疗前及治疗后14天进行神经功能评估，治疗后3个月进行日常生活能力评估，比较近期疗效及远期预后。结果治疗组和对照组血清Hcy水平在治疗前均有不同程度升高，治疗后Hcy水平下降，两组比较差异有统计学意义（P<0.05）。治疗组和对照组治疗后NIHSS评分降低，两组比较差异有统计学意义（P<0.05）。结论高Hcy血症与急性脑梗死的发生密切相关，急性期应用尤瑞克林能降低Hcy水平，早期改善症状，为防治脑梗死进展提供新的理论依据。
목적：연구혈청동형반광안산（Hcy）수평여급성뇌경사발병적관계급약물간예치료후동형반광안산수평변화급예후분석。방법수집100례급성뇌경사환자，치료조50례、대조조50례，분별우치료전급치료후7천채취혈액표본，채용매련면역법측정Hcy，비교치료조여대조조혈청Hcy수평변화，치료전급치료후14천진행신경공능평고，치료후3개월진행일상생활능력평고，비교근기료효급원기예후。결과치료조화대조조혈청Hcy수평재치료전균유불동정도승고，치료후Hcy수평하강，량조비교차이유통계학의의（P<0.05）。치료조화대조조치료후NIHSS평분강저，량조비교차이유통계학의의（P<0.05）。결론고Hcy혈증여급성뇌경사적발생밀절상관，급성기응용우서극림능강저Hcy수평，조기개선증상，위방치뇌경사진전제공신적이론의거。
Objective To study the relationship of serum homocysteine(Hcy)and the aetiological agent of acute cerebral infarction. And the change of Hcy level after drug intervention. Methods 100 cases of patients with acute cerebral infarction were divided into control group and treatment group,50 cases of each group. 7 days before and after treatment the blood samples of the patients were taken. The content of Hcy was detected by enzyme linked immunosorbent assay. The contents of Hcy were compared between two groups. 14 days before and after treatment,the nerve functional assessment was evaluated. 3 months after treatment,the ability of daily life was evaluated. The curative effect and prognosis were compared. Results The levels of Hcy in the treatment group and the control group were increased before the treatment. After treatment,the level of Hcy was reduced,there was significant difference between two groups(P<0.05). After treatment,the NIHSS score was lower than before in the treatment group and control group,there was significant difference between two groups(P<0.05). Conclusion There is a very close relationship between high Hcy hyperlipidemia and acute cerebral infarction. Urinarykal id can reduce the level of Hcy at acute stage. The medicine can also improve the early symptoms. The medicine can provide a new theoretical basis for the prevention and treatment of cerebral infarction.