CAJ | 학술논문

目的：观察卡托普利联合尿毒清颗粒治疗糖尿病肾病的临床效果及对蛋白尿的影响。方法将我院自2013年12月～2014年8月收治的糖尿病肾病患者63例随机分为两组。其中对照组30例在降糖、降压、对症治疗的基础上加用卡托普利治疗；联合组33例则服用卡托普利的同时服用尿毒清颗粒。治疗时间为1个月。观察和比较两组治疗前后的血肌酐、24 h尿微量白蛋白、24 h尿蛋白变化。结果血肌酐同期两组比较或同组治疗前后比较均无差异（P>0.05）。治疗后联合组24 h尿微量白蛋白、24 h尿蛋白均降低较对照组变化更显著（P<0.05）结论卡托普利联合尿毒清颗粒可以减小患者肾功能衰竭的危险因素，为延缓肾衰竭提供有利条件。
목적：관찰잡탁보리연합뇨독청과립치료당뇨병신병적림상효과급대단백뇨적영향。방법장아원자2013년12월～2014년8월수치적당뇨병신병환자63례수궤분위량조。기중대조조30례재강당、강압、대증치료적기출상가용잡탁보리치료；연합조33례칙복용잡탁보리적동시복용뇨독청과립。치료시간위1개월。관찰화비교량조치료전후적혈기항、24 h뇨미량백단백、24 h뇨단백변화。결과혈기항동기량조비교혹동조치료전후비교균무차이（P>0.05）。치료후연합조24 h뇨미량백단백、24 h뇨단백균강저교대조조변화경현저（P<0.05）결론잡탁보리연합뇨독청과립가이감소환자신공능쇠갈적위험인소，위연완신쇠갈제공유리조건。
Objective To observe the efficacy on captopril combined with uremic clearance granule for treating proteinuria in patients with diabetic nephropathy. Methods 63 cases with diabetic nephropathy from December 2013 to Augest 2014 were randomly divided into two groups in our hospital. 30 cases in control group treating with captopril therapy based on blood glucose and blood pressure,symptomatic treatment. 33 cases in combination group took captopril and uremic clearance granule. Treatment time was 1 months. Serum creatinine,24h urinary albumin,24 h urine total protein were tested before and after treatment. Results Serum creatinine compared showed no significant difference(P>0.05). The combination group 24h urinary albumin and 24h urine total protein were lower than in the control group after treatment(P<0.05). Conclusion The risk factors of captopril combined with uremic clearance granule can be reduced in patients with renal failure,provide favorable conditions for delaying renal failure.