中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
11期
103-104
,共2页
甘精胰岛素%阿卡波糖%老年%2型糖尿病
甘精胰島素%阿卡波糖%老年%2型糖尿病
감정이도소%아잡파당%노년%2형당뇨병
insulin glargine%acarbose%old man%senile type 2 diabetes mellitus
目的：观察甘精胰岛素联合阿卡波糖治疗老年糖尿病的临床疗效。方法选取老年2型糖尿病患者60例，随机均分为治疗组和对照组。治疗前护理人员对所有患者的基本情况进行评估，在整个过程中对其进行健康教育、饮食护理、运动护理、预防低血糖等。治疗组采用甘精胰岛素联合阿卡波糖治疗，甘精胰岛素皮下注射、1次/日，阿卡波糖片口服、3次/日；对照组采用门冬胰岛素30皮下注射，早晚餐前各1次。16周后评价两组疗效。结果治疗组餐后2 h血糖明显高于对照组（ P <0.05），糖化血红蛋白水平高于对照组（ P<0.05），低血糖发生率明显低于对照组（ P<0.05），两组空腹血糖、体重指数无显著性差异（ P>0.05）；治疗组低密度脂蛋白胆固醇低于治疗前水平（ P<0.05），血压、总胆固醇、三酰甘油、高密度脂蛋白胆固醇与治疗前相比无统计学差异（ P>0.05）。结论甘精胰岛素联合阿卡波糖治疗老年糖尿病，能较好控制患者血糖，且低血糖发生率低，依从性好，值得临床推广。
目的：觀察甘精胰島素聯閤阿卡波糖治療老年糖尿病的臨床療效。方法選取老年2型糖尿病患者60例，隨機均分為治療組和對照組。治療前護理人員對所有患者的基本情況進行評估，在整箇過程中對其進行健康教育、飲食護理、運動護理、預防低血糖等。治療組採用甘精胰島素聯閤阿卡波糖治療，甘精胰島素皮下註射、1次/日，阿卡波糖片口服、3次/日；對照組採用門鼕胰島素30皮下註射，早晚餐前各1次。16週後評價兩組療效。結果治療組餐後2 h血糖明顯高于對照組（ P <0.05），糖化血紅蛋白水平高于對照組（ P<0.05），低血糖髮生率明顯低于對照組（ P<0.05），兩組空腹血糖、體重指數無顯著性差異（ P>0.05）；治療組低密度脂蛋白膽固醇低于治療前水平（ P<0.05），血壓、總膽固醇、三酰甘油、高密度脂蛋白膽固醇與治療前相比無統計學差異（ P>0.05）。結論甘精胰島素聯閤阿卡波糖治療老年糖尿病，能較好控製患者血糖，且低血糖髮生率低，依從性好，值得臨床推廣。
목적：관찰감정이도소연합아잡파당치료노년당뇨병적림상료효。방법선취노년2형당뇨병환자60례，수궤균분위치료조화대조조。치료전호리인원대소유환자적기본정황진행평고，재정개과정중대기진행건강교육、음식호리、운동호리、예방저혈당등。치료조채용감정이도소연합아잡파당치료，감정이도소피하주사、1차/일，아잡파당편구복、3차/일；대조조채용문동이도소30피하주사，조만찬전각1차。16주후평개량조료효。결과치료조찬후2 h혈당명현고우대조조（ P <0.05），당화혈홍단백수평고우대조조（ P<0.05），저혈당발생솔명현저우대조조（ P<0.05），량조공복혈당、체중지수무현저성차이（ P>0.05）；치료조저밀도지단백담고순저우치료전수평（ P<0.05），혈압、총담고순、삼선감유、고밀도지단백담고순여치료전상비무통계학차이（ P>0.05）。결론감정이도소연합아잡파당치료노년당뇨병，능교호공제환자혈당，차저혈당발생솔저，의종성호，치득림상추엄。
Objective To observe the clinical effect of insulin glargine combined with acarbose in treating senile diabetes and to analyze its nursing. Methods 60 elderly patients with type 2 diabetes mellitus ( T2DM ) were selected and divided into the treatment group and the control group randomly and equally. The nursing staff conducted the evaluation on the basic situation of all patients before treatment and performed the health education, dietary nursing, exercise nursing, hypoglycemia prevention, etc. The treatment group was treated by in-sulin glargine combined with acarbose, insulin glargine by subcutaneous injection once daily, oral acarbose tablets 3 times daily;the con-trol group adopted the Insulin Aspart 30 Injection by subcutaneous injection, once before breakfast and again before dinner. The fasting and postprandial blood glucose level, glycated hemoglobin and incidence of hypoglycemia after 16 weeks were observed and compared between the two groups. The blood pressure and blood lipids in the treatment group were compared between before and after treat-ment. Results The postprandial 2 h blood glucose level in the treatment group was significantly higher than that in the control group ( P < 0. 05 ) , the glycated hemoglobin level was higher than that in the control group ( P < 0. 05 ) , the incidence rate of hypoglycemia was lower than that in the control group ( P < 0. 05 );the fasting blood glucose and body mass index had no statistically significant dif-ference between the two groups ( P > 0. 05 );the low density lipoprotein cholesterol after treatment in the treatment group was lower than that before treatment ( P < 0. 05 );the blood pressure, total cholesterol, triacylglycerol and high density lipoprotein cholesterol had no sta-tistical differences compared with those before treatment ( P > 0. 05 ) . Conclusion Insulin glargine combined with acarbose could better control the blood sugar level in elderly patients with T2DM, and has low incidence rate of hypoglycemia and good compliance, which is worth popularization in clinic.
