CAJ | 학술논문

目的：探讨奥拉西坦联合丁苯酞治疗血管性认知障碍患者的临床疗效。方法将138例血管性认知障碍患者按照随机数字表法分为两组，各69例。对照组给予奥拉西坦治疗，观察组在对照组基础上联合丁苯酞治疗，疗程均为4周。分析两组患者治疗前后认知障碍分度标准（MMSE）评分、日常生活活动能力（ADL）评分及蒙特利尔认知评估（MoCA）各项目评分。结果观察组治疗后MMSE评分显著高于对照组，ADL评分显著低于对照组，定向力、延迟回忆、注意力及视空间与执行能力评分显著高于对照组（ P<0.05）。结论奥拉西坦联合丁苯酞治疗血管性认知障碍的临床疗效显著，值得推广。
목적：탐토오랍서탄연합정분태치료혈관성인지장애환자적림상료효。방법장138례혈관성인지장애환자안조수궤수자표법분위량조，각69례。대조조급여오랍서탄치료，관찰조재대조조기출상연합정분태치료，료정균위4주。분석량조환자치료전후인지장애분도표준（MMSE）평분、일상생활활동능력（ADL）평분급몽특리이인지평고（MoCA）각항목평분。결과관찰조치료후MMSE평분현저고우대조조，ADL평분현저저우대조조，정향력、연지회억、주의력급시공간여집행능력평분현저고우대조조（ P<0.05）。결론오랍서탄연합정분태치료혈관성인지장애적림상료효현저，치득추엄。
Objective To investigate the clinical effect of oxiracetam combined with butylphthalide in the treatment of the patients with vascular cognitive impairment. Methods 138 cases of vascular cognitive impairment were randomly divided into the observation group and the control group according to the random number table, 69 cases in each group. The control group received the oxiracetam treat-ment, while on this basis the observation group was combined with the butylphthalide therapy. The two groups were treated for 4 weeks. The mini-mental state examination ( MMSE ) score, activities of daily life ( ADL ) score and MoCA score before and after treatment were compared between the two groups. Results The MMSE scores after treatment in the observation group were significantly higher than those in the control group, while the ADL scores were significantly lower than those in the control group, the differences were sta-tistically different ( P < 0. 05 );the orientation, delayed recall, attention and visuospatial ability and execution ability scores after treatment in the observation group were significantly higher than those in the control group with statistically significant difference ( P < 0. 05 ) . Conclusion Oxiracetam combined with butylphthalide has significant effect for treating vascular cognitive impairment and important clinical significance.