中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
11期
78-79
,共2页
曲安奈德%卡介菌多糖核酸%利多卡因%口腔扁平苔藓
麯安奈德%卡介菌多糖覈痠%利多卡因%口腔扁平苔蘚
곡안내덕%잡개균다당핵산%리다잡인%구강편평태선
triamcinolone acetonide%BCG polysaccharide nucleic acid%lidocaine%oral lichen planus(OLP)
目的：探讨曲安奈德联合卡介菌多糖核酸在口腔扁平苔藓治疗中的临床疗效。方法选取2013年6月至2014年6月在医院就诊的口腔扁平苔藓患者120例，按照随机数字表法分为治疗组和对照组，各60例。两组均给予醋酸曲安奈德+利多卡因局部黏膜下注射，每周1次，共用4周。治疗组同时给予卡介菌多糖核酸注射液肌肉注射，隔日1次，共18次。结果治疗1周后治疗组总有效率为93.33%，明显高于对照组的80.00%（ P<0.05）；治疗后1周，治疗组糜烂面积较治疗前减少（ P<0.05）；治疗后2周及治疗后4周，两组患者糜烂面积均较治疗前明显减少（ P<0.05），且治疗组较对照组减少明显（ P<0.05）；治疗后1，2，4周两组患者疼痛程度均较治疗前降低（ P<0.05），治疗组较对照组降低明显（ P<0.05）；治疗组不良反应发生率（11.67%）与对照组（10.00%）相比无明显差异（ P>0.05）；治疗3个月后，治疗组复发率为5.00%，明显低于对照组的13.33%（ P<0.05）。结论曲安奈德联合卡介菌多糖核酸治疗口腔扁平苔藓中，疗效可靠，能有效减少糜烂面积，降低疼痛程度及复发率，且不良反应发生率低，值得临床推广。
目的：探討麯安奈德聯閤卡介菌多糖覈痠在口腔扁平苔蘚治療中的臨床療效。方法選取2013年6月至2014年6月在醫院就診的口腔扁平苔蘚患者120例，按照隨機數字錶法分為治療組和對照組，各60例。兩組均給予醋痠麯安奈德+利多卡因跼部黏膜下註射，每週1次，共用4週。治療組同時給予卡介菌多糖覈痠註射液肌肉註射，隔日1次，共18次。結果治療1週後治療組總有效率為93.33%，明顯高于對照組的80.00%（ P<0.05）；治療後1週，治療組糜爛麵積較治療前減少（ P<0.05）；治療後2週及治療後4週，兩組患者糜爛麵積均較治療前明顯減少（ P<0.05），且治療組較對照組減少明顯（ P<0.05）；治療後1，2，4週兩組患者疼痛程度均較治療前降低（ P<0.05），治療組較對照組降低明顯（ P<0.05）；治療組不良反應髮生率（11.67%）與對照組（10.00%）相比無明顯差異（ P>0.05）；治療3箇月後，治療組複髮率為5.00%，明顯低于對照組的13.33%（ P<0.05）。結論麯安奈德聯閤卡介菌多糖覈痠治療口腔扁平苔蘚中，療效可靠，能有效減少糜爛麵積，降低疼痛程度及複髮率，且不良反應髮生率低，值得臨床推廣。
목적：탐토곡안내덕연합잡개균다당핵산재구강편평태선치료중적림상료효。방법선취2013년6월지2014년6월재의원취진적구강편평태선환자120례，안조수궤수자표법분위치료조화대조조，각60례。량조균급여작산곡안내덕+리다잡인국부점막하주사，매주1차，공용4주。치료조동시급여잡개균다당핵산주사액기육주사，격일1차，공18차。결과치료1주후치료조총유효솔위93.33%，명현고우대조조적80.00%（ P<0.05）；치료후1주，치료조미란면적교치료전감소（ P<0.05）；치료후2주급치료후4주，량조환자미란면적균교치료전명현감소（ P<0.05），차치료조교대조조감소명현（ P<0.05）；치료후1，2，4주량조환자동통정도균교치료전강저（ P<0.05），치료조교대조조강저명현（ P<0.05）；치료조불량반응발생솔（11.67%）여대조조（10.00%）상비무명현차이（ P>0.05）；치료3개월후，치료조복발솔위5.00%，명현저우대조조적13.33%（ P<0.05）。결론곡안내덕연합잡개균다당핵산치료구강편평태선중，료효가고，능유효감소미란면적，강저동통정도급복발솔，차불량반응발생솔저，치득림상추엄。
Objective To research the clinical efficacy of triamcinolone combined with BCG polysaccharide nucleic acid in the treatment of oral lichen planus ( OLP ) . Methods 120 cases of OLP in our hospital from June 2013 to June 2014 were selected and randomly di-vided into the treatment group and the control group according to the random number table method, 60 cases in each group. The two groups were given triamcinolone acetonide acetate + lidocaine by local submucosal injection once a week for 4 weeks. The treatment group was simultaneously given BCG polysaccharide nucleic acid by intramuscular injection, once every other day, for18 times. The situa-tion of erosion area and pain, etc. Results The total effective rate in the treatment group was 93. 33%, which was significantly higher than 80. 00% in the control group ( P < 0. 05 ); the erosion area after 1-week treatment in the two groups was decreased compared with before treatment ( P < 0. 05 );the erosion area after 2-week and 4-week treatment in the two groups was significantly decreased compared with before treatment ( P < 0. 05 ) , moreover the decrease in the treatment group was more significant than that in the control group ( P < 0. 05 ) . The pain degree after 1-, 2-, 4- week treatment in the two groups was decreased compared with before treatment ( P < 0. 05 ) , moreover the decrease in the treatment group was more significant than that in the control group ( P < 0. 05 ); the inci-dence rate of adverse reactions had no statistically significant difference between the treatment group and the control group ( 10. 00%vs. 11. 67%, P > 0. 05 );the recurrence rate after 3-month treatment in the treatment group was 5. 00%, which was significantly lower than 13. 33% in the control group, the difference was statistically significant ( P < 0. 05 ) . Conclusion Triamcinolone acetonide acetate combined with BCG polysaccharide nucleic acid has reliable effect in the treatment of OLP, can effectively reduce the erosion area, de-creases the pain degree and recurrence rate with low incidence rate of adverse reactions, and is worthy of promotion in clinic.
