CAJ | 학술논문

目的：了解胎膜早破孕妇生殖道病原菌的分布及其耐药情况，为临床合理使用抗生素提供指导。方法对2011～2013年3162例胎膜早破孕妇生殖道标本进行一般细菌培养、支原体培养、衣原体检测，使用 VITEKⅡ型全自动微生物鉴定仪进行鉴定和药敏试验；所有数据采用 WHONET5.6软件进行回顾分析。结果感染率为33.30％。其中细菌、真菌、支原体培养及沙眼衣原体抗原检测的阳性率分别为13.19％，4.87％，24.89％和2.72％。大肠埃希菌产超广谱β内酰胺酶（ESBLS）的比率为13.76％，耐甲氧西林金黄色葡萄球菌（MRSA）和耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）的比率分别为27.27％和66.25％。支原体对米诺霉素、强力霉素最敏感。结论支原体感染为第一位，其次为细菌，临床应加强感染病原学监测，根据药敏试验结果合理使用抗生素。
목적：료해태막조파잉부생식도병원균적분포급기내약정황，위림상합리사용항생소제공지도。방법대2011～2013년3162례태막조파잉부생식도표본진행일반세균배양、지원체배양、의원체검측，사용 VITEKⅡ형전자동미생물감정의진행감정화약민시험；소유수거채용 WHONET5.6연건진행회고분석。결과감염솔위33.30％。기중세균、진균、지원체배양급사안의원체항원검측적양성솔분별위13.19％，4.87％，24.89％화2.72％。대장애희균산초엄보β내선알매（ESBLS）적비솔위13.76％，내갑양서림금황색포도구균（MRSA）화내갑양서림응고매음성포도구균（MRCNS）적비솔분별위27.27％화66.25％。지원체대미낙매소、강력매소최민감。결론지원체감염위제일위，기차위세균，림상응가강감염병원학감측，근거약민시험결과합리사용항생소。
Objective To investigate the distribution and drug resistance of genital tract pathogens in pregnant women with premature rupture of membranes (PROM),and provide guidance for clinical rational use of antibiotics.Methods From 2011 to 2013,3 162 cases of patients with premature rupture of membranes were cultured for bacteria,Mycoplasma and Chlamydia.Identification and drug sensitive test of the bacteria were detected by VITEK II system;all of the data were ana-lyzed by WHONET5.6 software.Results The rate of infection was 33.30%,in which the positive rate of bacteria,Fung, Mycoplasma culture and Chlamydia trachomatis antigen detection were 13.19%,4.87%,24.89% and 2.72% respectively. The ratio of Escherichia coli producing extended spectrum beta lactamases (ESBLS)were 13.76%.The ratio of Methicillin resistant Staphylococcus aureus (MRSA)and Methicillin resistant coagulase negative Staphylococcus (MRCNS)were 27.27%and 66.25% respectively.Mycoplasma was most sensitive to minocycline,doxycycline.Conclusion Mycoplasma in-fection was the first,followed by bacteria.clinical should strengthen the surveillance of pathogen infection,and rational use of antibiotics according to the results of drug sensitive test.