CAJ | 학술논문

目的：了解医院大肠埃希菌感染特点及药物敏感情况，为临床抗感染治疗提供依据。方法收集医院2011年1月至2013年12月住院部送检标本中分离的大肠埃希菌，采用VITEK2 COMPACT全自动微生物分析系统，对临床标本分离细菌进行菌种鉴定及药物敏感性试验分析检测。结果在分离的1904株大肠埃希菌中，来自泌尿外科的菌株最多，为305株（16.02%）；检出标本以痰液所占比例最高（41.70%），尿液次之（31.46%）；分离出的大肠埃希菌对各类抗菌药物的敏感性以厄他培南最高，对氨苄西林、头孢唑林、左氧氟沙星有不同程度的耐药。结论大肠埃希菌在医院获得性感染中存在比较严重的耐药情况，尽早进行细菌培养和耐药监测，可指导临床合理用药，避免产生更多耐药株。
목적：료해의원대장애희균감염특점급약물민감정황，위림상항감염치료제공의거。방법수집의원2011년1월지2013년12월주원부송검표본중분리적대장애희균，채용VITEK2 COMPACT전자동미생물분석계통，대림상표본분리세균진행균충감정급약물민감성시험분석검측。결과재분리적1904주대장애희균중，래자비뇨외과적균주최다，위305주（16.02%）；검출표본이담액소점비례최고（41.70%），뇨액차지（31.46%）；분리출적대장애희균대각류항균약물적민감성이액타배남최고，대안변서림、두포서림、좌양불사성유불동정도적내약。결론대장애희균재의원획득성감염중존재비교엄중적내약정황，진조진행세균배양화내약감측，가지도림상합리용약，피면산생경다내약주。
Objective To understand the clinical features and the drug sensitivity situation of Escherichia coli infection in hospital to provide the basis for clinical anti-infection treatment. Methods :Escherichia coli strains isolated from the submitted specimens in the inpatient department from January 2011 to December 2013 were performed the bacterial identification dug susceptibility test by adopting the VITEK2 COMPACT automatic microbial analysis system produced by France bioMerieux company. Results Among the isolated 1 904 strains of Escherichia coli, 305 strains ( 16. 02% ) were derived from the urology department, the detection specimens were highest from sputum specimens ( 41. 70%) , followed by the urine specimens ( 31. 46%) . Most of isolated Escherichia coli strains were sensitive to er-tapenem and resistant to ampicillin, cefazolin, levofloxacin in varying degrees. Conclusion :The serious resistance of Escherichia coli iso-lated from hospital acquired infection to antibacterial drugs exists. Therefore conducting the surveillance of Escherichia coli drug resis-tance as early as possible can guide clinical rational drug use and avoid the generation of more drug resistant strains.