中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
11期
55-56,57
,共3页
厄贝沙坦胶囊%叠氮化物%离子色谱法
阨貝沙坦膠囊%疊氮化物%離子色譜法
액패사탄효낭%첩담화물%리자색보법
irbesartan capsule%azide%ion chromatography
目的：建立测定厄贝沙坦中叠氮化物残留量的离子色谱法。方法采用IonPac AG11－HC保护柱（50 mm ×4 mm），IonPac AS11－HC分析柱（250 mm ×4 mm）；淋洗液采用低浓度的 KOH溶液、梯度洗脱，柱温30℃，进样量25μL。结果叠氮化物离子质量浓度在0.542～2.168μg/mL范围内与峰面积线性关系良好（ r=0.9997），方法检测限为0.25 ng，定量限为1.25 ng。结论该法简单快速，专属性强，结果准确，灵敏度高，可用于厄贝沙坦中叠氮化物残留量的检测。
目的：建立測定阨貝沙坦中疊氮化物殘留量的離子色譜法。方法採用IonPac AG11－HC保護柱（50 mm ×4 mm），IonPac AS11－HC分析柱（250 mm ×4 mm）；淋洗液採用低濃度的 KOH溶液、梯度洗脫，柱溫30℃，進樣量25μL。結果疊氮化物離子質量濃度在0.542～2.168μg/mL範圍內與峰麵積線性關繫良好（ r=0.9997），方法檢測限為0.25 ng，定量限為1.25 ng。結論該法簡單快速，專屬性彊，結果準確，靈敏度高，可用于阨貝沙坦中疊氮化物殘留量的檢測。
목적：건립측정액패사탄중첩담화물잔류량적리자색보법。방법채용IonPac AG11－HC보호주（50 mm ×4 mm），IonPac AS11－HC분석주（250 mm ×4 mm）；림세액채용저농도적 KOH용액、제도세탈，주온30℃，진양량25μL。결과첩담화물리자질량농도재0.542～2.168μg/mL범위내여봉면적선성관계량호（ r=0.9997），방법검측한위0.25 ng，정량한위1.25 ng。결론해법간단쾌속，전속성강，결과준학，령민도고，가용우액패사탄중첩담화물잔류량적검측。
Objective To establish an ion chromatography method for the determination of the azides residual amount in Irbesartan Ccapsules. Methods The method was established by using the IonPac AG11-HC ( 50 mm × 4 mm ) as the protection column and the IonPac AS11-HC ( 250 mm × 4 mm ) as the analytical column;the elution solution adopted the low concentration of KOH-solution, the gradient elution was adopted. The column temperature was 30 ℃;the sample size was 25 μL. Results The linear range of azide ion was 0. 542-2. 168 μg/mL ( r=0. 999 7 ) . The detection limit of azide by this method was 0. 25 ng; the quantity limit of azide was 1. 25 ng. Conclusion The established method is simple, rapid, strongly specific, accurate, highly sensitive and suitable for the determina-tion of azide residue in irbesartan.
