CAJ | 학술논문

目的：探讨前列地尔联合纤溶酶治疗内听动脉闭塞综合征的临床疗效。方法选取内听动脉闭塞综合征患者88例，随机均分为试验组和对照组。两组均给予常规基础治疗，试验组加用前列地尔和纤溶酶。比较两组患者的临床疗效，检测治疗前后脑干听觉诱发电位、全血比黏度和血小板聚集率，记录不良反应发生情况。结果试验组治疗总有效率为95.45%，高于对照组的77.27%（ P<0.05）。治疗后，除峰间潜伏期（IPL）Ⅰ～Ⅲ无明显变化外，两组IPLⅢ～Ⅴ，IPLⅠ～Ⅴ均较治疗前有显著改善，试验组优于对照组（ P<0.05），组间比较，潜伏期（PL）Ⅰ差异无统计学意义（ P>0.05），PLⅢ，PLⅤ试验组均好于对照组（ P<0.05）。治疗后，两组患者全血比黏度、血小板聚集率均较治疗前有显著改善，且试验组改善程度优于对照组（ P<0.05）。治疗过程中，均未出现影响治疗的不良反应。结论前列地尔联合纤溶酶治疗内听动脉闭塞综合征的临床效果显著，不良反应少，值得临床推广。
목적：탐토전렬지이연합섬용매치료내은동맥폐새종합정적림상료효。방법선취내은동맥폐새종합정환자88례，수궤균분위시험조화대조조。량조균급여상규기출치료，시험조가용전렬지이화섬용매。비교량조환자적림상료효，검측치료전후뇌간은각유발전위、전혈비점도화혈소판취집솔，기록불량반응발생정황。결과시험조치료총유효솔위95.45%，고우대조조적77.27%（ P<0.05）。치료후，제봉간잠복기（IPL）Ⅰ～Ⅲ무명현변화외，량조IPLⅢ～Ⅴ，IPLⅠ～Ⅴ균교치료전유현저개선，시험조우우대조조（ P<0.05），조간비교，잠복기（PL）Ⅰ차이무통계학의의（ P>0.05），PLⅢ，PLⅤ시험조균호우대조조（ P<0.05）。치료후，량조환자전혈비점도、혈소판취집솔균교치료전유현저개선，차시험조개선정도우우대조조（ P<0.05）。치료과정중，균미출현영향치료적불량반응。결론전렬지이연합섬용매치료내은동맥폐새종합정적림상효과현저，불량반응소，치득림상추엄。
Objective To investigate the clinical efficacy of alprostadil combined with plasmin in treating internal auditory artery occlu-sion syndrome. Methods 88 cases of internal auditory artery occlusion syndrome were chosen and randomly divided into the control group and experimental group. The two groups were given the routine basic therapy, whereas the experimental group was added with al-prostadil and plasmin. The clinical effects were compared between the two groups. The brain stem auditory evoked potential, whole blood specific viscosity and platelet aggregation rate were detected before and after treatment. The occurrence situation of adverse reactions was recorded. Results The total effective rate in the experimental group was 95. 45% , which was higher than 77. 27% in the control group, the difference was statistically significant ( P < 0. 05 ) . Except for no obvious change in IPL Ⅰ~Ⅲ, the other indexes in the two groups were significantly improved compared with before treatment ( P < 0. 05 );the difference in PL Ⅰbetween the two groups had no statistical significance ( P > 0. 05 ) , the other indexes in the experimental group were better than those in the control group ( P < 0. 05 ) . The whole blood specific viscosity and platelet aggregation rate after treatment in the two groups were obviously improved compared with before treatment, moreover the improvement degree in the experimental group was greater than that in the control group with statis-tical difference ( P < 0. 05 ) . Conclusion Alprostadil combined with plasmin has obvious effect and less adverse reactions for treating internal auditory artery occlusion syndrome and is worthy of being promoted in clinic.