CAJ | 학술논문

器官移植的术后排斥反应是影响移植器官生存率的主要问题。microRNA-155（miR-155）被认为是免疫稳态的一种关键性调节因子，在炎症反应、抗原呈递、淋巴细胞分化和细胞因子产生等控制排斥免疫过程中发挥重要作用，因此可能成为控制排斥反应的新治疗靶点，以及作为排斥反应的生物标记物。
기관이식적술후배척반응시영향이식기관생존솔적주요문제。microRNA-155（miR-155）피인위시면역은태적일충관건성조절인자，재염증반응、항원정체、림파세포분화화세포인자산생등공제배척면역과정중발휘중요작용，인차가능성위공제배척반응적신치료파점，이급작위배척반응적생물표기물。
Organ transplantation has become one of the most important means to treat end-stage organ diseases, but allograft rejection remains a major problem affecting the survival rate of transplanted organs. MicroRNA-155 (miR-155) is considered to be a key regulator in immune homeostasis. Increasing observations show that miR-155, a center regulator in the process of inflammatory response, antigen presentation, lymphocyte differentiation, cytokine production and so on, plays an important role in the development of transplant rejection. More and more evidences show the differential expression of miR-155 along with the presence of organ transplant rejections, suggesting that miR-155 could be a biomarker of organ transplant rejection.