CAJ | 학술논문

目的：分析新生儿真菌败血症的相关因素，进一步探讨其早期诊断、防治方法。方法对2007年3月1日—2012年3月1日期间住我院新生儿科确诊的新生儿真菌败血症10例进行回顾性分析。结果10例中白色假丝酵母菌5例，光滑假丝酵母菌2例，其他假丝酵母菌2例，克柔假丝酵母菌1例。使用有创呼吸机3例，无创呼吸机4例，中心静脉置管8例，持续使用广谱抗菌药物8例，进入新生儿重症监护室（NICU）治疗10例（100%），粒细胞减少4例，可能为相关因素；死亡1例。结论新生儿真菌败血症以白色假丝酵母菌属为主，非白色假丝酵母菌属感染比例增多，早产儿是NICU中真菌感染高危儿，深部真菌感染病例中中心静脉置管率较高，与呼吸机应用相关。对于有高危因素疑诊深部真菌感染者应早期开始经验性治疗、预防。
목적：분석신생인진균패혈증적상관인소，진일보탐토기조기진단、방치방법。방법대2007년3월1일—2012년3월1일기간주아원신생인과학진적신생인진균패혈증10례진행회고성분석。결과10례중백색가사효모균5례，광활가사효모균2례，기타가사효모균2례，극유가사효모균1례。사용유창호흡궤3례，무창호흡궤4례，중심정맥치관8례，지속사용엄보항균약물8례，진입신생인중증감호실（NICU）치료10례（100%），립세포감소4례，가능위상관인소；사망1례。결론신생인진균패혈증이백색가사효모균속위주，비백색가사효모균속감염비례증다，조산인시NICU중진균감염고위인，심부진균감염병례중중심정맥치관솔교고，여호흡궤응용상관。대우유고위인소의진심부진균감염자응조기개시경험성치료、예방。
Objective To analyze some possible factors of fungus sepsis,and further discuss its early diagnosis, prevention and cure. Method 10 cases of newborn neonatal sepsis which try to be cured in our hospital during 2007.03.01~2012.03.01 were clinically analyzed in a retrospective sense. Results In the total 10 cases,5 cases indicates Candida albicans, 2 case shows smooth candida,2 cases with other candida,and 1 case represents Candida krusei. In the respective of therapy,various methods have been carried out,including sub-invasive ventilator breathing machine(3 cases),Noninvasive ventilator (4 cases),Peripherally Inserted Central Catheter (PICC)(8 cases),continuous taking antibacterial drugs(8 cases), enter NICU therapy(100%) and granulocytopenia(4 cases),and died(1case).Conclusion The Candida albicans are the main part, The infection rates of others increase .premature infants NICU is in highly risk in fungal infection, The rate of PICC is higher in deep fungus infections, which also related to ventilator application. Risk factors for suspected fungal infection of the deep diagnosis should be empirically treated and prevented early.