基层医学论坛
基層醫學論罈
기층의학론단
PUBLIC MEDICAL FORUM MAGAZINE
2015年
16期
2167-2169
,共3页
ASCUS%HPV检测%阴道镜%活组织检查
ASCUS%HPV檢測%陰道鏡%活組織檢查
ASCUS%HPV검측%음도경%활조직검사
ASCUS%HPV%Detection of colposcopy%Biopsy
目的：探讨宫颈细胞学检查为意义不明确的非典型鳞状细胞（ASCUS）进一步处理的临床路径。方法对198例宫颈细胞学检查诊断为ASCUS的患者，联合采用PCR-反向杂交法进行人乳头状瘤病毒（HPV）基因检测及分型和阴道镜检查及镜下活组织检查。结果 ASCUS主要分布在31岁~50岁年龄段，HPV基因检测及分型检查共检出62例阳性者，感染率为31.31%，HPV高危亚型的感染率≤30岁组与41岁~55岁组明显高于31岁~40岁组，为2个明显的高峰期。198例ASCUS中包含各种宫颈病变，具体组织学检查结果为：炎症158例（79.80%），CINⅠ级30例（15.15%），CINⅡ级3例（1.52%），CINⅢ级4例（2.02%），原位癌2例，浸润癌1例，共3例（1.52%）。HPV阳性患者中的宫颈CIN及以上病变检出率显著高于HPV阴性患者。结论对宫颈细胞学检查为ASCUS的患者，应联合HPV基因检测及分型和阴道镜下活组织检查，以提高宫颈病变筛查的阳性率。
目的：探討宮頸細胞學檢查為意義不明確的非典型鱗狀細胞（ASCUS）進一步處理的臨床路徑。方法對198例宮頸細胞學檢查診斷為ASCUS的患者，聯閤採用PCR-反嚮雜交法進行人乳頭狀瘤病毒（HPV）基因檢測及分型和陰道鏡檢查及鏡下活組織檢查。結果 ASCUS主要分佈在31歲~50歲年齡段，HPV基因檢測及分型檢查共檢齣62例暘性者，感染率為31.31%，HPV高危亞型的感染率≤30歲組與41歲~55歲組明顯高于31歲~40歲組，為2箇明顯的高峰期。198例ASCUS中包含各種宮頸病變，具體組織學檢查結果為：炎癥158例（79.80%），CINⅠ級30例（15.15%），CINⅡ級3例（1.52%），CINⅢ級4例（2.02%），原位癌2例，浸潤癌1例，共3例（1.52%）。HPV暘性患者中的宮頸CIN及以上病變檢齣率顯著高于HPV陰性患者。結論對宮頸細胞學檢查為ASCUS的患者，應聯閤HPV基因檢測及分型和陰道鏡下活組織檢查，以提高宮頸病變篩查的暘性率。
목적：탐토궁경세포학검사위의의불명학적비전형린상세포（ASCUS）진일보처리적림상로경。방법대198례궁경세포학검사진단위ASCUS적환자，연합채용PCR-반향잡교법진행인유두상류병독（HPV）기인검측급분형화음도경검사급경하활조직검사。결과 ASCUS주요분포재31세~50세년령단，HPV기인검측급분형검사공검출62례양성자，감염솔위31.31%，HPV고위아형적감염솔≤30세조여41세~55세조명현고우31세~40세조，위2개명현적고봉기。198례ASCUS중포함각충궁경병변，구체조직학검사결과위：염증158례（79.80%），CINⅠ급30례（15.15%），CINⅡ급3례（1.52%），CINⅢ급4례（2.02%），원위암2례，침윤암1례，공3례（1.52%）。HPV양성환자중적궁경CIN급이상병변검출솔현저고우HPV음성환자。결론대궁경세포학검사위ASCUS적환자，응연합HPV기인검측급분형화음도경하활조직검사，이제고궁경병변사사적양성솔。
Objective To investigate the cervical cytology is ambiguous atypical squamous cells(ASCUS)of clinical pathway for further processing. Methods 198 cases of cervical cytology in patients diagnosed with ASCUS, combined with human papilloma virus by PCR-reverse dot blot (HPV) gene detection and typing and vaginoscopy and pathologic biopsy. Results ASCUS was mainly distributed in the 31-50 age,HPV gene detection and typing examination were detected positive in 62 cases,the infection rate was 31.31%, high-risk subtypes of HPV infection rate is less than or equal to 30 years old group and 41~55 years old group was higher than that of 31~40 years old group ,2 obvious peak. In 198 cases of ASCUS contains a variety of cervical lesions, the specific histology results for:inflammation in 158 cases(79.80%),30 cases of CIN I(15.15%), 3 cases with CIN II(1.52%),4 cases of CIN III(2.02%),2 cases of carcinoma in situ, invasive carcinoma in 1 cases,3 cases (1.52%). Detection rate of HPV in patients with positive cervical CIN and above lesions were significantly higher than that of HPV negative patients. Conclusion the cervical cytology with ASCUS should be combined with detection of HPV gene and type and biopsy under colposcope,to increase the positive rate of screening for cervical lesions.
