高等学校化学学报
高等學校化學學報
고등학교화학학보
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES
2015年
6期
1236-1242
,共7页
仿生黏合剂%聚乙二醇单甲醚-聚赖氨酸-g-3 ,4-二羟基苯丙酸%聚乙二醇单甲醚-聚谷氨酸-g-3 ,4-二羟基苯丙胺%邻苯二酚%可降解黏合剂
倣生黏閤劑%聚乙二醇單甲醚-聚賴氨痠-g-3 ,4-二羥基苯丙痠%聚乙二醇單甲醚-聚穀氨痠-g-3 ,4-二羥基苯丙胺%鄰苯二酚%可降解黏閤劑
방생점합제%취을이순단갑미-취뢰안산-g-3 ,4-이간기분병산%취을이순단갑미-취곡안산-g-3 ,4-이간기분병알%린분이분%가강해점합제
Bioadhesive%mPEG-b-P( LL-g-DHPPA)%mPEG-b-P( LG-g-Dopamine)%o-Dihydroxybenzene%Degradable adhesive
以氨基化聚乙二醇( mPEG-NH2)为大分子引发剂,制备了基于邻苯二酚[如3,4-二羟基苯丙酸(DHPPA)和3,4-二羟基苯丙胺即多巴胺(Dopamine)]的仿生黏合剂聚乙二醇单甲醚-聚赖氨酸-g-3,4-二羟基苯丙酸[mPEG-b-P(LL-g-DHPPA)]和聚乙二醇单甲醚-聚谷氨酸-g-3,4-二羟基苯丙胺[mPEG-b-P(LG-g-Dopamine)].用核磁共振波谱( NMR)、傅里叶变换红外光谱( FTIR)和凝胶渗透色谱( GPC)等方法表征了mPEG-b-P( LL-g-DHPPA)和mPEG-b-P( LG-g-Dopamine)的结构. mPEG-b-P( LL-g-DHPPA)和mPEG-b-P( LG-g-Dopamine)的接枝度分别为30%和28.6%,即每个聚合物分子链上分别接上了13.5个DHPPA单体和13个Dopamine单体.剪切强度测试结果表明, mPEG-b-P( LL-g-DHPPA)更有利于黏合剂的固化并能提高黏合剂的内聚强度.
以氨基化聚乙二醇( mPEG-NH2)為大分子引髮劑,製備瞭基于鄰苯二酚[如3,4-二羥基苯丙痠(DHPPA)和3,4-二羥基苯丙胺即多巴胺(Dopamine)]的倣生黏閤劑聚乙二醇單甲醚-聚賴氨痠-g-3,4-二羥基苯丙痠[mPEG-b-P(LL-g-DHPPA)]和聚乙二醇單甲醚-聚穀氨痠-g-3,4-二羥基苯丙胺[mPEG-b-P(LG-g-Dopamine)].用覈磁共振波譜( NMR)、傅裏葉變換紅外光譜( FTIR)和凝膠滲透色譜( GPC)等方法錶徵瞭mPEG-b-P( LL-g-DHPPA)和mPEG-b-P( LG-g-Dopamine)的結構. mPEG-b-P( LL-g-DHPPA)和mPEG-b-P( LG-g-Dopamine)的接枝度分彆為30%和28.6%,即每箇聚閤物分子鏈上分彆接上瞭13.5箇DHPPA單體和13箇Dopamine單體.剪切彊度測試結果錶明, mPEG-b-P( LL-g-DHPPA)更有利于黏閤劑的固化併能提高黏閤劑的內聚彊度.
이안기화취을이순( mPEG-NH2)위대분자인발제,제비료기우린분이분[여3,4-이간기분병산(DHPPA)화3,4-이간기분병알즉다파알(Dopamine)]적방생점합제취을이순단갑미-취뢰안산-g-3,4-이간기분병산[mPEG-b-P(LL-g-DHPPA)]화취을이순단갑미-취곡안산-g-3,4-이간기분병알[mPEG-b-P(LG-g-Dopamine)].용핵자공진파보( NMR)、부리협변환홍외광보( FTIR)화응효삼투색보( GPC)등방법표정료mPEG-b-P( LL-g-DHPPA)화mPEG-b-P( LG-g-Dopamine)적결구. mPEG-b-P( LL-g-DHPPA)화mPEG-b-P( LG-g-Dopamine)적접지도분별위30%화28.6%,즉매개취합물분자련상분별접상료13.5개DHPPA단체화13개Dopamine단체.전절강도측시결과표명, mPEG-b-P( LL-g-DHPPA)경유리우점합제적고화병능제고점합제적내취강도.
Macromolecular initiator aminated monomethoxy poly ( ethylene glycol ) ( abbreviated as mPEG-NH2 ) was synthesized to get mimic bioadhesives mPEG-b-P ( LL-g-DHPPA ) and mPEG-b-P ( LG-g-Dopa-mine) . The structures of target products were confirmed by nuclear magnetic resonance ( NMR ) , Fourier transform infrared spectroscopy ( FTIR ) and gel permeation chromatography ( GPC ) , and the degree of the catechol moiety grafting density of these two polymers were tested to be 30% and 28. 6%, respectively. The results of tensile stripping experiments demonstrated that the mimic bioadhesive that bearing amino groups on its side chain[ i. e. , mPEG-b-P( LL-g-DHPPA) ] exhibited higher adhesive strength and faster curing speed.
