CAJ | 학술논문

目的：探讨血中肌钙蛋白I(cTnI)、肌钙蛋白T(cTnT)、N端前B型脑钠肽(NT-proBNP)联合检测在急性心肌梗死(acute myocardial infarction，AMI)诊断中的应用价值。方法选取急性胸闷胸痛为主要症状的患者34例，以2010年AMI临床诊断与治疗指南将受试者分为AMI组（n=20）和非AMI组（n=14）。就诊时即抽取血样，用电化学发光法法测定入组者血浆中的cTnI、cTnT、NT-proBNP的浓度。结果 AMI患者NT-proBNP浓度均值为3580.40 pg/mL，非AMI组为167.6 pg/mL，NT-proBNP浓度较对照组明显升高，差异有统计学意义(P＜0.05)；cTnI、cTnT浓度较非AMI组亦明显升高，差异有统计学意义(P＜0.05)。结论 NT-proBNP、cTnI、cTnT联合检测可以使AMI检测的敏感性升高，有助于AMI的早期诊断。
목적：탐토혈중기개단백I(cTnI)、기개단백T(cTnT)、N단전B형뇌납태(NT-proBNP)연합검측재급성심기경사(acute myocardial infarction，AMI)진단중적응용개치。방법선취급성흉민흉통위주요증상적환자34례，이2010년AMI림상진단여치료지남장수시자분위AMI조（n=20）화비AMI조（n=14）。취진시즉추취혈양，용전화학발광법법측정입조자혈장중적cTnI、cTnT、NT-proBNP적농도。결과 AMI환자NT-proBNP농도균치위3580.40 pg/mL，비AMI조위167.6 pg/mL，NT-proBNP농도교대조조명현승고，차이유통계학의의(P＜0.05)；cTnI、cTnT농도교비AMI조역명현승고，차이유통계학의의(P＜0.05)。결론 NT-proBNP、cTnI、cTnT연합검측가이사AMI검측적민감성승고，유조우AMI적조기진단。
Objective Investigate the value of serum Cardiac troponin I, cardiac troponin T and NT-proBNP combined detection in acute myocardial infarction diagnose.Methods Collected 34 patients who have the with acute chest pain as the main symptom treatment for the study, the blood samples were drawn when the patients in the treatment, all the samples use electricity chemiluminescence method to detect the plasma cTnI, cTnT, NT-proBNP concentrations.Results NT-proBNP concentration in patients with AMI mean is 3580.40 pg/mL, the control group was 167.6 pg/mL, compared with the control group was significantly higher in patients with NT-proBNP, the difference was statistically significant (P<0.05);plasma cTnI、cTnT compared with the control group also significantly increased, the difference was statistically significant(P<0.05).Conclusion NT-proBNP, cTnI, cTnT combined detection of AMI detection sensitivity can be improved to help early diagnosis of AMI.