CAJ | 학술논문

目的：探讨血药浓度监测在氟西汀治疗抑郁症中的临床应用价值。方法：收集我院心理科2013年1-12月使用氟西汀治疗的58例抑郁症患者的病例资料，按是否予于血药浓度监测分为观察组（n＝32）和对照组（n＝26）。血药浓度于口服氟西汀6 h后采用高效液相色谱仪检测。比较两组患者治疗前和治疗1、2、4、8周后的《汉密尔顿抑郁量表》和《不良反应量表》评分。结果：治疗1、2、4和8周后，观察组患者的《汉密尔顿抑郁量表》和《不良反应量表》评分均显著低于同期的对照组患者（P均＜0.05），但两组患者在治疗8周后的总有效率相当，分别为87.5%和84.6%，差异比较无统计学意义。结论：根据氟西汀血药浓度监测结果制定个体化给药方案有利于提高患者预后并减少不良反应的发生。
목적：탐토혈약농도감측재불서정치료억욱증중적림상응용개치。방법：수집아원심이과2013년1-12월사용불서정치료적58례억욱증환자적병례자료，안시부여우혈약농도감측분위관찰조（n＝32）화대조조（n＝26）。혈약농도우구복불서정6 h후채용고효액상색보의검측。비교량조환자치료전화치료1、2、4、8주후적《한밀이돈억욱량표》화《불량반응량표》평분。결과：치료1、2、4화8주후，관찰조환자적《한밀이돈억욱량표》화《불량반응량표》평분균현저저우동기적대조조환자（P균＜0.05），단량조환자재치료8주후적총유효솔상당，분별위87.5%화84.6%，차이비교무통계학의의。결론：근거불서정혈약농도감측결과제정개체화급약방안유리우제고환자예후병감소불량반응적발생。
Objective: To study the clinical application and the serum concentration monitoring of fluoxerine for depression.Methods: The clinical data of 58 cases of patients with depression, who were treated in 2013 at the psychology department of our hospital, were divided into an observation group (n=32) and a control group (n=26). The serum concentrations of lfuoxetine in the observation group were monitored by HPLC 6 hours after taking lfuoxetine. The Hamilton Depression Scale (HAMD) and Treatment Emergent Symptom Scale (TESS) of patients were compared between two groups before treatment and hereafter 1, 2, 4, 8 weeks.Results: The HAMD and TESS scores were signiifcantly lower in the observation group than in the control group during that period (P<0.05). However, the total efficiency in two groups was almost equal after eight weeks treatment, which was 87.5% in the observation group and 84.6% in the control group, the difference was not statistically signiifcant.Conclusion: It’s important to formulate individualized dosing regimen based on the results of serum concentration monitoring of lfuoxetine in order to improve the prognosis of patients and reduce the incidence of adverse reaction.