CAJ | 학술논문

沉默信息调节因子1为烟酰胺腺嘌呤二核苷酸依赖的脱乙酰化酶，其功能广泛而复杂，包括在细胞存活、增殖等过程中都有重要的生理作用。研究发现沉默信息调节因子1可调节糖、脂代谢，且对炎症反应有一定的抑制作用，故有可能通过抑制血尿酸水平升高、阻断炎症反应而对慢性痛风反复发作产生一定的预防作用。本文介绍沉默信息调节因子1的主要生物学功能及其与痛风和高尿酸血症的关联。
침묵신식조절인자1위연선알선표령이핵감산의뢰적탈을선화매，기공능엄범이복잡，포괄재세포존활、증식등과정중도유중요적생리작용。연구발현침묵신식조절인자1가조절당、지대사，차대염증반응유일정적억제작용，고유가능통과억제혈뇨산수평승고、조단염증반응이대만성통풍반복발작산생일정적예방작용。본문개소침묵신식조절인자1적주요생물학공능급기여통풍화고뇨산혈증적관련。
SIRT1 is a nicotinamide adenine dinucleotide-dependent class III histone deacetylase. It has been shown to be involved in a variety of pathophysiological processes, such as cell growth and proliferation. Recent research work showed thatSIRT1 could regulate metabolism modulation such as glycometabolism and lipid metabolism, and had a certain inhibition of inlfammatory response and accordingly might have a preventive effect on the recurrent attacks of gouty arthritis by its inhibition of the inlfammation and hyperuricemia. Here we review the biological properties ofSIRT1 and its possible functions for the treatment of gout and hyperuricemia.