CAJ | 학술논문

痛风是由嘌呤代谢障碍引起的一种代谢性疾病。急性痛风性关节炎是痛风的最常见首发症状，传统治疗药物包括非甾体抗炎药物、秋水仙碱和糖皮质激素。炎性细胞因子在急性痛风性关节炎的发病中起着重要作用，故能阻断炎症介质如白介素-1、肿瘤坏死因子-α等的生物制剂有望在该疾病治疗中得到广泛的应用。本文就急性痛风性关节炎的药物治疗作一概要介绍。
통풍시유표령대사장애인기적일충대사성질병。급성통풍성관절염시통풍적최상견수발증상，전통치료약물포괄비치체항염약물、추수선감화당피질격소。염성세포인자재급성통풍성관절염적발병중기착중요작용，고능조단염증개질여백개소-1、종류배사인자-α등적생물제제유망재해질병치료중득도엄범적응용。본문취급성통풍성관절염적약물치료작일개요개소。
Gout is a kind of metabolic disease caused by purine metabolic disorders. Acute gouty arthritis (AGR) is usually the initial symptom for gout. Traditional medicines for the treatment of AGR include non-steroid anti-inlfammatory drugs, colchicines, corticosteroids. Inlfammatory cytokines play an key role in the pathogenesis of AGR, therefore, biologicals that can block inlfammatory cytokines such as interleukin-1, tumor necrosis factor-α are expected to be widely used in the treatment of AGR. Here we mainly review medicine treatment of AGR and hope it can provide some help for further research.