CAJ | 학술논문

基质金属蛋白酶(matrix metalloproteinases,MMPs)是一个锌、钙依赖性的内肽酶家族,是细胞外基质(ECM)降解的主要介质,表达和激活都受到严密的调控。基质金属蛋白酶活性可以被组织金属蛋白酶抑制剂(tissue inhibitor of matrix metallopro-teinases,TIMPs)控制,进而降低其表达。基质金属蛋白酶与组织金属蛋白酶抑制剂比例适当是维持心脏正常运行的重要因素。基质金属蛋白酶与组织金属蛋白酶抑制剂共同维持细胞外基质的平衡并且基质金属蛋白酶还参与了许多心血管疾病的发生发展过程,合理调控 MMPs 的表达与活性有利于心血管疾病的治疗。
기질금속단백매(matrix metalloproteinases,MMPs)시일개자、개의뢰성적내태매가족,시세포외기질(ECM)강해적주요개질,표체화격활도수도엄밀적조공。기질금속단백매활성가이피조직금속단백매억제제(tissue inhibitor of matrix metallopro-teinases,TIMPs)공제,진이강저기표체。기질금속단백매여조직금속단백매억제제비례괄당시유지심장정상운행적중요인소。기질금속단백매여조직금속단백매억제제공동유지세포외기질적평형병차기질금속단백매환삼여료허다심혈관질병적발생발전과정,합리조공 MMPs 적표체여활성유리우심혈관질병적치료。
Matrix metalloproteinases,a family of endopeptidases which is relied on zinc and calium,is primary mediator to degrade Extra Cellular Matrix.The expression and activation of MMPs are under the precise control.The activity of Matrix metalloproteinases can be controlled by tissue inhibitor of matrix met-alloproteinases,and their expression can also be declined by TIMPs.The proper proportion of Matrix metal-loproteinases and tissue inhibitor of matrix metalloproteinases plays an important role in keeping normal op-eration of heart .MMPs and TIMPs keep the balance of ECM together.Then MMPs participate in the genesis and development of a variety of cardiovascular diseases,reasonable regulation of MMPs expression and activ-ity is benefit to the treatment of cardiovascular diseases.